{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T15:15:32Z","timestamp":1718896532332},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal undernutrition affects various physiological functions, such as metabolic and reproductive functions, after birth, and such changes are associated with the pathogeneses of certain diseases. It has been hypothesized that these changes are predictive adaptive responses that help individuals to endure similar conditions in the postnatal period. Thus, we evaluated the effects of prenatal undernutrition on the responses of the body weight (BW) regulation system and reproductive functions to fasting in the pre\u2010pubertal period in male rats. Prenatally normally nourished and undernourished rats exhibited similar reductions in BW and visceral fat after 48\u2009h fasting in the pre\u2010pubertal period. Furthermore, these two groups displayed similar fasting\u2010induced patterns of change in their hypothalamic levels of appetite regulatory factors; i.e., neuropeptide Y and pro\u2010opiomelanocortin. These results indicate that prenatal undernutrition had no marked effects on BW regulation in male rats. On the other hand, serum luteinizing hormone and testosterone levels were decreased by 48\u2009h fasting in the prenatally normally nourished rats, whereas the levels of these hormones did not change in the prenatally undernourished rats. However, the hypothalamic mRNA level of kisspeptin 1 (Kiss1), which is a positive regulator of gonadotropin\u2010releasing hormone\/gonadotropins, was reduced by fasting in both groups. These results indicate that prenatal undernutrition might attenuate fasting\u2010induced reproductive dysfunction in the postnatal period; however, these changes might not be induced by alterations in the hypothalamic Kiss1 system. Further studies are needed to clarify the mechanisms involved in these changes in reproductive function.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.07.005","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T18:29:38Z","timestamp":1531852178000},"page":"30-33","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prenatal undernutrition attenuates fasting\u2010induced reproductive dysfunction in pre\u2010pubertal male rats"],"prefix":"10.1002","volume":"71","author":[{"given":"Takeshi","family":"Iwasa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Biomedical Sciences, Tokushima University Graduate School 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Biomedical Sciences, Tokushima University Graduate School 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohito","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Biomedical Sciences, Tokushima University Graduate School 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiliyasi","family":"Mayila","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Biomedical Sciences, Tokushima University Graduate School 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Irahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Institute of Biomedical Sciences, Tokushima University Graduate School 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00634-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90740.2008"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1415"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1263"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095292"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1344s"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301817110"},{"key":"e_1_2_5_9_1","first-page":"821","article-title":"Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats","volume":"588","author":"Iwasa T.","year":"2010","journal-title":"J. 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