{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:41:20Z","timestamp":1774050080751,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:00:00Z","timestamp":1535587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several environmental factors affect child development, such as the intrauterine environment during the embryonic and fetal development and early postnatal environment provided by maternal behavior. Although mechanistic effects of maternal exercise on offspring health improvement are not yet completely understood, the number of reports published demonstrating the positive influence of maternal exercise have increase. Herein, we addressed issues related to early postnatal environment provided by maternal behavior and early developmental physical landmarks, sensorimotor reflexes, and motor movements ontogeny. In brief, adult female rats underwent involuntary swimming exercise, in a moderated intensity, one week before mating and throughout pregnancy, 30\u2009min a day, 5 days a week. Maternal exercised dams have unchanged gestational outcomes compared to sedentary dams. We found no differences concerning the frequency of pup\u2010directed behavior displayed by dams. However, sedentary dams displayed a poorer pattern of maternal care quality during dark cycle than exercised dams. Physical landmarks and sensorimotor reflexes development of female and male littermates did not differ between maternal groups. Developmental motor parameters such as immobility, lateral head movements, head elevation, pivoting, rearing with forelimb support and crawling frequencies did not differ between groups. Pups born to exercised dams presented higher frequency of walking and rearing on the hind legs. These data suggest that female and male littermates of exercised group present a high frequency of exploratory behavior over sedentary littermates. Taken together, the present findings reinforce that maternal exercise throughout pregnancy represent a window of opportunity to improve offspring's postnatal health.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.08.009","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T19:00:54Z","timestamp":1535655654000},"page":"83-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Swimming exercise before and during pregnancy: Promising preventive approach to impact offspring's health"],"prefix":"10.1002","volume":"71","author":[{"given":"Caroline Peres","family":"Klein","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Bioqu\u00edmica Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline","family":"dos Santos Rodrigues","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Bioqu\u00edmica Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gis Mateus","family":"H\u00f6zer","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Bioqu\u00edmica Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natividade","family":"de S\u00e1 Couto\u2010Pereira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Neuroci\u00eancias, Instituto de Ci\u00eancias B\u00e1sicas, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Brum","family":"Saccomori","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Mari\u00f1o","family":"Dal Magro","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Scortegagna","family":"Crestani","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Bender","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Bioqu\u00edmica Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christianne Gazzana","family":"Salbego","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Bioqu\u00edmica Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"},{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Dalmaz","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Bioqu\u00edmica Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"},{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"},{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Neuroci\u00eancias, Instituto de Ci\u00eancias B\u00e1sicas, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Matt\u00e9","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Biol\u00f3gicas\u2014Bioqu\u00edmica Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"},{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"},{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Fisiologia, Instituto de Ci\u00eancias B\u00e1sicas, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001214"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.10.051"},{"issue":"4","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/0003-3472(75)90114-1","article-title":"Postnatal development of locomotion in the laboratory rat","volume":"23","author":"Altman J.","year":"1975","journal-title":"Anim. Behav."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000223"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3818"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.215"},{"issue":"8489","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0140-6736(86)91340-1","article-title":"Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales","volume":"1","author":"Barker D.J.","year":"1986","journal-title":"Lancet"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02725"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.271460"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2013.02.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31827de953"},{"issue":"3","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0031-9384(03)00149-5","article-title":"Variations in maternal care in the rat as a mediating influence for the effects of environment on development","volume":"79","author":"Champagne F.A.","year":"2003","journal-title":"Physiol. Behav."},{"issue":"6","key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/S0022-3476(96)70029-X","article-title":"Morphometric and neurodevelopmental outcome at age five years of the offspring of women who continued to exercise regularly throughout pregnancy","volume":"129","author":"Clapp J.F.","year":"1996","journal-title":"J. Pediatr."},{"issue":"3","key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0002-9378(98)70444-2","article-title":"The one\u2010year morphometric and neurodevelopmental outcome of the offspring of women who continued to exercise regularly throughout pregnancy","volume":"178","author":"Clapp J.F.","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.107096"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2016.10.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S151613"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500018R"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420210707"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512001316"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2016.08.001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.01.039"},{"issue":"11","key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1073\/pnas.78.11.7226","article-title":"\u201cWarm\u2010up\u201d along dimensions of movement in the ontogeny of exploration in rats and other infant mammals","volume":"78","author":"Golani I.","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010017\u20104193\u20105"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400248"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.01.003"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11\u2010193193"},{"key":"e_1_2_8_29_1","unstructured":"C.J.Heyser.Assessment of developmental milestones in rodents.Current Protocols in Neuroscience.2004;1810.1002\/0471142301.ns0818s25 Chapter 8 Unit 8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.04.019"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060339"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.03.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2016.1227427"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487317737628"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2005.05.007"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000002416"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20101031\u20101_10"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.04.043"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.009"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2017.07.002"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.104968"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2012.01.010"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00126.2016"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.10.012"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20107614\u20100_7"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830513Y.0000000068"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.10.039"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13\u20101848"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17\u20100098"},{"issue":"1","key":"e_1_2_8_50_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/(SICI)1098-2302(199707)31:1<19::AID-DEV3>3.0.CO;2-X","article-title":"Offspring\u2010induced nurturance: animal\u2010human parallels","volume":"31","author":"Stern J.M.","year":"1997","journal-title":"Dev. Psychobiol."},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.19"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051351"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986\u2010015\u20100052\u2010z"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.05.010"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574818301680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574818301680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2018.08.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2018.08.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2018.08.009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2018.08.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T21:39:00Z","timestamp":1694036340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2018.08.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,30]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1016\/j.ijdevneu.2018.08.009"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2018.08.009","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,30]]},"assertion":[{"value":"2018-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}