{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:01:47Z","timestamp":1790622107326,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HD057853"],"award-info":[{"award-number":["P01HD057853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by a core set of atypical behaviors in social\u2010communicative and repetitive\u2010motor domains. Individual profiles are widely heterogeneous and include language skills ranging from nonverbal to hyperlexic. The causal mechanisms underlying ASD remain poorly understood but appear to include a complex combination of polygenic and environmental risk factors. SHANK3 (SH3 and multiple ankyrin repeat domains 3) is one of a subset of well\u2010replicated ASD\u2010risk genes (i.e., genes demonstrating ASD associations in multiple studies), with haploinsufficiency of SHANK3 following deletion or de novo mutation seen in about 1% of non\u2010syndromic ASD. SHANK3 is a synaptic scaffolding protein enriched in the postsynaptic density of excitatory synapses. In order to more closely evaluate the contribution of SHANK3 to neurodevelopmental expression of ASD, a knockout mouse model with a mutation in the PDZ domain was developed. Initial research showed compulsive\/repetitive behaviors and impaired social interactions in these mice, replicating two core ASD features. The current study was designed to further examine Shank3B heterozygous and homozygous knockout mice for behaviors that might map onto atypical language in ASD (e.g., auditory processing, and learning\/memory). We report findings of repetitive and atypical aggressive social behaviors (replicating prior reports), novel evidence that Shank3B KO mice have atypical auditory processing (low\u2010level enhancements that might have a direct relationship with heightened pitch discrimination seen in ASD), as well as robust learning impairments.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.10.003","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T17:16:58Z","timestamp":1540833418000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Shank3B mutant mice display pitch discrimination enhancements and learning deficits"],"prefix":"10.1002","volume":"72","author":[{"given":"Amanda R.","family":"Rendall","sequence":"first","affiliation":[{"name":"Yale University School of Medicine, Pediatrics 464 Congress Ave New Haven 06520\u20108055 CT USA"},{"name":"University of Connecticut, Psychology\u2010Behavioral Neuroscience 406 Babbidge Road, Unit 1020 Storrs Mansfield 06269 CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Perrino","sequence":"additional","affiliation":[{"name":"University of Connecticut, Psychology\u2010Behavioral Neuroscience 406 Babbidge Road, Unit 1020 Storrs Mansfield 06269 CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexzandrea N.","family":"Buscarello","sequence":"additional","affiliation":[{"name":"University of Connecticut, Psychology\u2010Behavioral Neuroscience 406 Babbidge Road, Unit 1020 Storrs Mansfield 06269 CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Holly","family":"Fitch","sequence":"additional","affiliation":[{"name":"University of Connecticut, Psychology\u2010Behavioral Neuroscience 406 Babbidge Road, Unit 1020 Storrs Mansfield 06269 CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,29]]},"reference":[{"issue":"5","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2346","article-title":"Advances in autism genetics: on the threshold of a new neurobiology","volume":"9","author":"Abrahams B.S.","year":"2008","journal-title":"Nat Rev Genet"},{"issue":"1","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0033291700028099","article-title":"Autism as a strongly genetic disorder: evidence from a British twin study","volume":"25","author":"Bailey A.","year":"1995","journal-title":"Psychol. Med."},{"issue":"3","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.biopsych.2003.10.022","article-title":"White matter structure in autism: preliminary evidence from diffusion tensor imaging","volume":"55","author":"Barnea\u2010Goraly N.","year":"2004","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/dev.10032","article-title":"The importance of rapid auditory processing abilities to early language development: evidence from converging methodologies","volume":"40","author":"Benasich A.A.","year":"2002","journal-title":"Dev. Psychobiol."},{"issue":"1","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2040-2392-4-17","article-title":"SHANK3 haploinsufficiency: a \u201ccommon\u201d but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders","volume":"4","author":"Betancur C.","year":"2013","journal-title":"Mol. Autism"},{"issue":"1","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ajmg.b.30039","article-title":"Are phonological processing deficits part of the broad autism phenotype?","volume":"128","author":"Bishop D.V.","year":"2004","journal-title":"Am. J. Med. Genet. Part B: Neuropsychiatr. Genet."},{"issue":"3","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ejhg.2012.175","article-title":"Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders","volume":"21","author":"Boccuto L.","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"issue":"5","key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1046\/j.1471-4159.2002.00931.x","article-title":"ProSAP\/Shank proteins\u2013a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease","volume":"81","author":"Boeckers T.M.","year":"2002","journal-title":"J. Neurochem."},{"issue":"5","key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1469-7610.1994.tb02300.x","article-title":"A case\u2010control family history study of autism","volume":"35","author":"Bolton P.","year":"1994","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"2","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1086\/321293","article-title":"Disruption of the ProSAP2 gene in at (12; 22)(q24. 1; q13. 3) is associated with the 22q13. 3 deletion syndrome","volume":"69","author":"Bonaglia M.C.","year":"2001","journal-title":"Am. J. Hum. Genet."},{"issue":"10","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1136\/jmg.2005.038604","article-title":"Identification of a recurrent breakpoint within the SHANK3 gene in the 22q13. 3 deletion syndrome","volume":"43","author":"Bonaglia M.C.","year":"2006","journal-title":"J. Med. Genet."},{"issue":"9","key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.neuropsychologia.2010.04.020","article-title":"Enhanced pure\u2010tone pitch discrimination among persons with autism but not Asperger syndrome","volume":"48","author":"Bonnel A.","year":"2010","journal-title":"Neuropsychologia"},{"issue":"2","key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1162\/089892903321208169","article-title":"Enhanced pitch sensitivity in individuals with autism: a signal detection analysis","volume":"15","author":"Bonnel A.","year":"2003","journal-title":"J. Cogn. Neurosci."},{"issue":"1","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2040-2392-1-15","article-title":"Haploinsufficiency of the autism\u2010associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication","volume":"1","author":"Bozdagi O.","year":"2010","journal-title":"Mol. Autism"},{"issue":"1","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.31887\/DCNS.2009.11.1\/jdbuxbaum","article-title":"Multiple rare variants in the etiology of autism spectrum disorders","volume":"11","author":"Buxbaum J.D.","year":"2009","journal-title":"Dialogues Clin. Neurosci."},{"issue":"4","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tins.2005.01.008","article-title":"Spine architecture and synaptic plasticity","volume":"28","author":"Carlisle H.J.","year":"2005","journal-title":"Trends Neurosci."},{"issue":"7","key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/cercor\/bht028","article-title":"Knockdown of the dyslexia\u2010associated gene Kiaa0319 impairs temporal responses to speech stimuli in rat primary auditory cortex","volume":"24","author":"Centanni T.M.","year":"2013","journal-title":"Cereb. Cortex"},{"issue":"17","key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1523\/JNEUROSCI.4202-15.2016","article-title":"Knockdown of dyslexia\u2010gene Dcdc2 interferes with speech sound discrimination in continuous streams","volume":"36","author":"Centanni T.M.","year":"2016","journal-title":"J. Neurosci."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.05.009"},{"issue":"11","key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1176\/appi.ajp.2010.09101470","article-title":"Sibling recurrence and the genetic epidemiology of autism","volume":"167","author":"Constantino J.N.","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.016"},{"issue":"2","key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.conb.2005.03.001","article-title":"Why the frontal cortex in autism might be talking only to itself: local over\u2010connectivity but long\u2010distance disconnection","volume":"15","author":"Courchesne E.","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"issue":"7526","key":"e_1_2_7_24_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nature13772","article-title":"Synaptic, transcriptional and chromatin genes disrupted in autism","volume":"515","author":"De Rubeis S.","year":"2014","journal-title":"Nature"},{"issue":"6","key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/mp.2013.78","article-title":"The autism brain imaging data exchange: towards a large\u2010scale evaluation of the intrinsic brain architecture in autism","volume":"19","author":"Di Martino A.","year":"2014","journal-title":"Mol. Psychiatry"},{"issue":"40","key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"15767","DOI":"10.1523\/JNEUROSCI.1175-13.2013","article-title":"Shank3 deficiency induces NMDA receptor hypofunction via an actin\u2010dependent mechanism","volume":"33","author":"Duffney L.J.","year":"2013","journal-title":"J. Neurosci."},{"issue":"1","key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng1933","article-title":"Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders","volume":"39","author":"Durand C.M.","year":"2007","journal-title":"Nat. Genet."},{"issue":"1","key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/mp.2011.57","article-title":"SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin\u2010dependent mechanism","volume":"17","author":"Durand C.M.","year":"2012","journal-title":"Mol. Psychiatry"},{"issue":"6","key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/aur.1324","article-title":"More is less: pitch discrimination and language delays in children with optimal outcomes from autism","volume":"6","author":"Eigsti I.M.","year":"2013","journal-title":"Autism Res."},{"issue":"1","key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/aur.1883","article-title":"Shank3\u2010deficient rats exhibit degraded cortical responses to sound","volume":"11","author":"Engineer C.T.","year":"2018","journal-title":"Autism Res."},{"issue":"1","key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2007.07.013","article-title":"Use of a modified prepulse inhibition paradigm to assess complex auditory discrimination in rodents","volume":"76","author":"Fitch R.H.","year":"2008","journal-title":"Brain Res. Bull."},{"issue":"17","key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"7863","DOI":"10.1073\/pnas.0906232107","article-title":"De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia","volume":"107","author":"Gauthier J.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"9","key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tics.2011.07.003","article-title":"Genetics of autism spectrum disorders","volume":"15","author":"Geschwind D.H.","year":"2011","journal-title":"Trends Cogn. Sci."},{"issue":"4","key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0034739","article-title":"High proportion of 22q13 deletions and SHANK3 mutations in Chinese patients with intellectual disability","volume":"7","author":"Gong X.","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-6-65","article-title":"Amyloid beta protein\u2010induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2\/Shank3 scaffold","volume":"6","author":"Grabrucker A.M.","year":"2011","journal-title":"Mol. Neurodegener."},{"issue":"14","key":"e_1_2_7_36_1","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1177\/0883073815600872","article-title":"Phelan McDermid syndrome: from genetic discoveries to animal models and treatment","volume":"30","author":"Harony\u2010Nicolas H.","year":"2015","journal-title":"J. Child Neurol."},{"issue":"8","key":"e_1_2_7_37_1","first-page":"1","article-title":"Integrated model of de novo and inherited genetic variants yields greater power to identify risk genes","volume":"9","author":"He X.","year":"2013","journal-title":"PLoS Genet."},{"issue":"4","key":"e_1_2_7_38_1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/1469-7610.00143","article-title":"Pitch memory, labelling and disembedding in autism","volume":"44","author":"Heaton P.","year":"2003","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"6","key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s10803-005-0024-7","article-title":"Interval and contour processing in autism","volume":"35","author":"Heaton P.","year":"2005","journal-title":"J. Autism Dev. Disord."},{"issue":"2","key":"e_1_2_7_40_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0006-8993(97)01417-0","article-title":"Water version of the radial\u2010arm maze: learning in three inbred strains of mice","volume":"785","author":"Hyde L.A.","year":"1998","journal-title":"Brain Res."},{"issue":"1","key":"e_1_2_7_41_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/aur.1664","article-title":"Novel Shank3 mutant exhibits behaviors with face validity for autism and altered striatal and hippocampal function","volume":"10","author":"Jaramillo T.C.","year":"2017","journal-title":"Autism Res."},{"issue":"13","key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1016\/j.neuropsychologia.2009.06.015","article-title":"Auditory discrimination and auditory sensory behaviours in autism spectrum disorders","volume":"47","author":"Jones C.R.","year":"2009","journal-title":"Neuropsychologia"},{"issue":"4","key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/cercor\/bhl006","article-title":"Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry","volume":"17","author":"Just M.A.","year":"2006","journal-title":"Cereb. Cortex"},{"issue":"3","key":"e_1_2_7_44_1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11910-009-0029-2","article-title":"Genetics of autism spectrum disorders","volume":"9","author":"Kumar R.A.","year":"2009","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"6","key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/sj.ejhg.5201610","article-title":"Genetics of autism spectrum disorder","volume":"14","author":"Klauck S.M.","year":"2006","journal-title":"Eur. J. Hum. Genet."},{"issue":"47","key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"18448","DOI":"10.1523\/JNEUROSCI.3017-13.2013","article-title":"Loss of predominant Shank3 isoforms results in hippocampus\u2010dependent impairments in behavior and synaptic transmission","volume":"33","author":"Kouser M.","year":"2013","journal-title":"J. Neurosci."},{"issue":"4","key":"e_1_2_7_47_1","first-page":"1","article-title":"Subgrouping the autism \u201cspectrum\u201d: reflections on DSM\u20105","volume":"11","author":"Lai M.C.","year":"2013","journal-title":"PLoS Biol."},{"issue":"4","key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/DBP.0b013e3181d5d03b","article-title":"Autism spectrum disorder and co\u2010occurring developmental, psychiatric, and medical conditions among children in multiple populations of the United States","volume":"31","author":"Levy S.E.","year":"2010","journal-title":"J. Dev. Behav. Pediatr."},{"issue":"3","key":"e_1_2_7_49_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/tp.2015.23","article-title":"Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence","volume":"5","author":"Lisiecka D.M.","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"e_1_2_7_50_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2013.00605","article-title":"Approaches to local connectivity in autism using resting state functional connectivity MRI","volume":"7","author":"Maximo J.O.","year":"2013","journal-title":"Front. Hum. Neurosci."},{"issue":"7","key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1007\/s10803-016-2754-0","article-title":"Brief report: sensory reactivity in children with Phelan\u2013McDermid Syndrome","volume":"46","author":"Mieses A.M.","year":"2016","journal-title":"J. Autism Dev. Disord."},{"issue":"6","key":"e_1_2_7_52_1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1086\/522590","article-title":"Contribution of SHANK3 mutations to autism spectrum disorder","volume":"81","author":"Moessner R.","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"10","key":"e_1_2_7_53_1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/mp.2012.138","article-title":"Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts","volume":"18","author":"Moreno\u2010De\u2010Luca D.","year":"2013","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"e_1_2_7_54_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10803-005-0040-7","article-title":"Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception","volume":"36","author":"Mottron L.","year":"2006","journal-title":"J. Autism Dev. Disord."},{"issue":"3","key":"e_1_2_7_55_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0896-6273(00)80809-0","article-title":"Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor\/PSD\u201095\/GKAP complex and cortactin","volume":"23","author":"Naisbitt S.","year":"1999","journal-title":"Neuron"},{"issue":"7397","key":"e_1_2_7_56_1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature11011","article-title":"Patterns and rates of exonic de novo mutations in autism spectrum disorders","volume":"485","author":"Neale B.M.","year":"2012","journal-title":"Nature"},{"issue":"3","key":"e_1_2_7_57_1","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1542\/peds.2010-2825","article-title":"Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study","volume":"128","author":"Ozonoff S.","year":"2011","journal-title":"Pediatrics"},{"key":"e_1_2_7_58_1","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G.","year":"2004"},{"issue":"7344","key":"e_1_2_7_59_1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic\u2010like behaviours and striatal dysfunction","volume":"472","author":"Pe\u00e7a J.","year":"2011","journal-title":"Nature"},{"issue":"5","key":"e_1_2_7_60_1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nn.4260","article-title":"Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B\u2010\/\u2010mice","volume":"19","author":"Peixoto R.T.","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"1","key":"e_1_2_7_61_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1750-1172-3-14","article-title":"Deletion 22q13. 3 syndrome","volume":"3","author":"Phelan M.C.","year":"2008","journal-title":"Orphanet J. Rare Dis."},{"issue":"3","key":"e_1_2_7_62_1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000334260","article-title":"The 22q13. 3 deletion syndrome (Phelan\u2010McDermid syndrome)","volume":"2","author":"Phelan K.","year":"2011","journal-title":"Mol. Syndromol."},{"issue":"3","key":"e_1_2_7_63_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s41252-017-0029-1","article-title":"Auditory processing enhancements in the TS2\u2010Neo mouse model of timothy syndrome, a rare genetic disorder associated with autism Spectrum disorders","volume":"1","author":"Rendall A.R.","year":"2017","journal-title":"Adv. Neurodev. Disord."},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.02.006"},{"issue":"10","key":"e_1_2_7_65_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1001\/archpediatrics.2009.98","article-title":"Characteristics and concordance of autism spectrum disorders among 277 twin pairs","volume":"163","author":"Rosenberg R.E.","year":"2009","journal-title":"Arch. Pediatr. Adolesc. Med."},{"issue":"7397","key":"e_1_2_7_66_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature10945","article-title":"De novo mutations revealed by whole\u2010exome sequencing are strongly associated with autism","volume":"485","author":"Sanders S.J.","year":"2012","journal-title":"Nature"},{"key":"e_1_2_7_67_1","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8051861","article-title":"Actin\u2010dependent alterations of dendritic spine morphology in shankopathies","volume":"2016","author":"Sarowar T.","year":"2016","journal-title":"Neural Plast."},{"issue":"1","key":"e_1_2_7_68_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2040-2392-4-18","article-title":"Prospective investigation of autism and genotype\u2010phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency","volume":"4","author":"Soorya L.","year":"2013","journal-title":"Mol. Autism"},{"issue":"3","key":"e_1_2_7_69_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1469-7610.1989.tb00254.x","article-title":"A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden","volume":"30","author":"Steffenburg S.","year":"1989","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"4","key":"e_1_2_7_70_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijdevneu.2012.01.009","article-title":"Neocortical disruption and behavioral impairments in rats following in utero RNAi of candidate dyslexia risk gene Kiaa0319","volume":"30","author":"Szalkowski C.E.","year":"2012","journal-title":"Int. J. Dev. Neurosci."},{"issue":"1","key":"e_1_2_7_71_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000348431","article-title":"Knockdown of the candidate dyslexia susceptibility gene homolog Dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy","volume":"35","author":"Szalkowski C.E.","year":"2013","journal-title":"Dev. Neurosci."},{"issue":"5","key":"e_1_2_7_72_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/aur.1243","article-title":"Diffusion tensor imaging in autism spectrum disorder: a review","volume":"5","author":"Travers B.G.","year":"2012","journal-title":"Autism Res."},{"issue":"8","key":"e_1_2_7_73_1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/gbb.12170","article-title":"Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability","volume":"13","author":"Truong D.T.","year":"2014","journal-title":"Genes Brain Behav."},{"issue":"6","key":"e_1_2_7_74_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1037\/bne0000096","article-title":"Auditory processing and morphological anomalies in medial geniculate nucleus of Cntnap2 mutant mice","volume":"129","author":"Truong D.T.","year":"2015","journal-title":"Behav. Neurosci."},{"issue":"40","key":"e_1_2_7_75_1","doi-asserted-by":"crossref","first-page":"34839","DOI":"10.1074\/jbc.M111.258384","article-title":"Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses","volume":"286","author":"Verpelli C.","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"15","key":"e_1_2_7_76_1","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1093\/hmg\/ddr212","article-title":"Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3","volume":"20","author":"Wang X.","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"e_1_2_7_77_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1176\/appi.ajp.2011.11091447","article-title":"Differences in white matter fiber tract development present from 6 to 24 months in infants with autism","volume":"169","author":"Wolff J.J.","year":"2012","journal-title":"Am. J. Psychiatry"},{"issue":"19","key":"e_1_2_7_78_1","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1523\/JNEUROSCI.6107-11.2012","article-title":"Reduced excitatory neurotransmission and mild autism\u2010relevant phenotypes in adolescent Shank3 null mutant mice","volume":"32","author":"Yang M.","year":"2012","journal-title":"J. Neurosci."},{"issue":"1","key":"e_1_2_7_79_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11689-016-9150-0","article-title":"Developmental phenotype in Phelan\u2010McDermid (22q13. 3 deletion) syndrome: a systematic and prospective study in 34 children","volume":"8","author":"Zwanenburg R.J.","year":"2016","journal-title":"J. Neurodev. Disord."}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574818302181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574818302181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2018.10.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2018.10.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2018.10.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2018.10.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:05:22Z","timestamp":1694045122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2018.10.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,29]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1016\/j.ijdevneu.2018.10.003"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2018.10.003","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,29]]},"assertion":[{"value":"2018-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}