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Maternal dietary folate, a cofactor in one\u2010carbon metabolism, modulates neurogenesis and apoptosis in foetal brain neurons. We hypothesized that aberrant neuronal apoptosis may affect the development of the central nervous system during maternal folic acid deficiency, with evident effects because maternal folic acid deficiency modulates the microRNA\u201034a associated with Bcl\u20102 pathway during embryonic development. Four\u2010week\u2010old female Sprague\u2010Dawley rats were divided randomly into two groups (10 rats per group): a folate\u2010deficient diet group and a folate\u2010normal diet group. The diets were administered to the rats 60 d before mating, which was continued for the pregnant dams until parturition. Maternal folic acid deficiency increased neuronal apoptosis in the hippocampus and the cortex in the offspring. Furthermore, maternal folic acid deficiency increased the ratio of cleaved caspase\u20103\/caspase\u20103, followed by an increase in caspase\u20103 activity. Moreover, maternal folic acid deficiency downregulated Bcl\u20102 and upregulated Bax, and this effect associate with maternal folic acid deficient increases expression of microRNA\u201034a. Together, the present results indicate that maternal folic acid deficiency stimulates neuronal apoptosis via microRNA\u201034a associated with Bcl\u20102 signalling in rat offspring.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.11.002","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T17:05:45Z","timestamp":1542215145000},"page":"6-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Maternal folic acid deficiency stimulates neural cell apoptosis via miR\u201034a associated with Bcl\u20102 in the rat foetal brain"],"prefix":"10.1002","volume":"72","author":[{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Science School of Public Health, Tianjin Medical University Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenshu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science School of Public Health, Tianjin Medical University Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dezheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science School of Public Health, Tianjin Medical University Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xumei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science School of Public Health, Tianjin Medical University Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Administration School of Public Health, Tianjin Medical University Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Science School of Public Health, Tianjin Medical University Tianjin 300070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112061109"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7302"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.1.162"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.110.122044"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.20412"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000342692"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010015\u20102420\u20104"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010017\u20103232\u20105"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12300"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.08.018"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20208"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2017.11.037"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.07.044"},{"issue":"10","key":"e_1_2_9_15_1","first-page":"6760","article-title":"MicroRNA\u201034a negatively regulates anesthesia\u2010induced hippocampal apoptosis and memory impairment through FGFR1","volume":"7","author":"Jiang X.L.","year":"2014","journal-title":"Int. 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