{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:41:56Z","timestamp":1790836916116,"version":"4.1.0"},"reference-count":89,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T00:00:00Z","timestamp":1551139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The decline in neurogenesis is a very critical problem in Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin. Herein, we investigated the neurogenesis potential of quercetin in a rat model of Alzheimer's disease induced by amyloid\u2010beta injection. Rats were randomly divided into Control, Alzheimer\u2009+\u2009Saline and Alzheimer\u2009+\u2009Quercetin groups. Following the administration of Amyloid\u2010beta, rats in the Alzheimer\u2009+\u2009Quercetin group received 40\u2009mg\/kg\/day quercetin orally for one month. Our data demonstrated amyloid\u2010\u03b2 injection could impair learning and memory processing in rats indicated by passive avoidance test evaluation. We noted that one\u2010month quercetin treatment alleviated the detrimental effects of amyloid\u2010\u03b2 on spatial learning and memory parameters using Morris water maze analysis. Quercetin was found to increase the number of proliferating neural stem\/progenitor cells. Notably, quercetin increased the number of DCX\u2010expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus. We further observed that the quercetin improved the number of BrdU\/NeuN positive cells contributed to enhanced adult neurogenesis. Based on our results, quercetin had the potential to promote the expression of\n                    <jats:italic>BDNF<\/jats:italic>\n                    ,\n                    <jats:italic>NGF<\/jats:italic>\n                    ,\n                    <jats:italic>CREB<\/jats:italic>\n                    , and\n                    <jats:italic>EGR<\/jats:italic>\n                    \u20101 genes involved in regulating neurogenesis. These data suggest that quercetin can play a valuable role in alleviating Alzheimer's disease symptoms by enhancing adult neurogenesis mechanism.\n                  <\/jats:p>","DOI":"10.1016\/j.ijdevneu.2019.02.005","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T11:38:25Z","timestamp":1551181105000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Quercetin promotes learning and memory performance concomitantly with neural stem\/progenitor cell proliferation and neurogenesis in the adult rat dentate gyrus"],"prefix":"10.1002","volume":"74","author":[{"given":"Mohammad","family":"Karimipour","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Stem Cell Research Center, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Neuroscience Research Center Advanced Biomedical Faculty Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Rahbarghazi","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Tayefi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shimia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ghanadian","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Faculty of Pharmacy Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Advanced Biomedical Faculty Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesam Saghaei","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.03.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12149"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2010.06.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/75705"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1995.1015"},{"key":"e_1_2_8_7_1","first-page":"3","volume-title":"Ngf, bdnf, nt3, and nt4","author":"Bothwell M.","year":"2014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-009-9411-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720506777632817"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10874"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8310-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1078"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.06.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173215"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03813.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(02)00421-7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2334169100"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23319"},{"key":"e_1_2_8_20_1","first-page":"4","article-title":"Neuroprotective effects of Rosa damascena extract on learning and memory in a rat model of amyloid\u2010\u03b2\u2010induced Alzheimer's disease","author":"Esfandiary E.","year":"2015","journal-title":"Adv. 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