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Valproic acid (VPA), a teratogen is known to induce characteristic features related to ASD in rodents. Numerous studies suggest the potential therapeutic effects of peroxisome proliferator\u2010activated receptor\u2010gamma (PPAR\u2010\u03b3) in different brain disorders. This research evaluates the utility of selective agonist of PPAR\u2010\u03b3, pioglitazone in prenatal VPA induced experimental ASD symptomatology in Wistar rats. The prenatal administration of VPA has induced social impairment, repetitive behavior, hyperlocomotion, anxiety and low exploratory activity in rats. Also, prenatal VPA\u2010treated rats have shown higher levels of oxidative stress (increased in thiobarbituric acid reactive species, and decreased in reduced glutathione level) and inflammation (increased in interleukin\u20106, tumor necrosis factor\u2010alpha and decreased in interleukin\u201010) in the cerebellum, brainstem and prefrontal cortex. Treatment with pioglitazone significantly attenuated the prenatal VPA\u2010induced social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity. Furthermore, pioglitazone also reduced the prenatal VPA\u2010induced oxidative stress and neuroinflammation in aforementioned brain regions. Hence, it may be concluded that pioglitazone may provide neurobehavioral and biochemical benefits in prenatal VPA\u2010induced autistic phenotypes in rats.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2019.05.006","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T18:02:20Z","timestamp":1558548140000},"page":"6-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Beneficial effects of pioglitazone, a selective peroxisome proliferator\u2010activated receptor\u2010\u03b3 agonist in prenatal valproic acid\u2010induced behavioral and biochemical autistic like features in Wistar rats"],"prefix":"10.1002","volume":"76","author":[{"given":"Roohi","family":"Mirza","sequence":"first","affiliation":[{"name":"Department of Pharmacology Amity Institute of Pharmacy Amity University Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Amity Institute of Pharmacy Amity University Uttar Pradesh India"},{"name":"CNS Pharmacology Conscience Research Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.02.041"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906\u2010017\u20101763\u20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders. 5. 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