{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T15:29:41Z","timestamp":1746199781232,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1504807"],"award-info":[{"award-number":["U1504807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The goal of this study was to investigate the effect of estradiol in mediation of electroencephalogram (EEG) abnormality induced by etomidate in neonatal rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sprague\u2010Dawley rats were anesthetized using intraperitoneal etomidate for 2\u2009h on postnatal days (P) 4, 5, or 6 and recorded electroencephalogram in two ways. First, pups were recorded EEG two and a half hours under etomidate anesthesia, in subgroups, estradiol receptor antagonist ICI182780 and estradiol synthase inhibitor formestane were given subcutaneously in male rats 15\u2009min prior to etomidate. Second, pups were anesthetized with etomidate for 2\u2009h on P4,5 or 6 and then recovered from anesthesia, EEG were recorded for one hour in two postnatal periods of P9\u2010P11 and P14\u2010P16. Subgroup rats that received bumetanide, NKCC1 inhibitor, to test the NKCC1\u2010GABAAR signaling effect on neonatal brain development, negative control groups and maternally separated for 2\u2009h on P4, 5, or 6 were studied in 16 groups. Each group's n was\u2009=\u20098.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Male pups showed more severe seizure\u2010like activities than female pups in P4\u2010P6 under etomidate anesthesia. Pups pretreated with ICI182780 and formestane showed a less abnormalities of EEG in male rats. Etomidate caused seizure\u2010like activity in P4\u2010P6 could extend to P9\u2010P11, but not seen in P14\u2010P16, Pretreated with bumetanide only alleviated abnormalities in male pups other than female in P9\u2010P11.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Estradiol involves in the NKCC1\u2010GABA<jats:sub>A<\/jats:sub>R mediated seizure\u2010like activity caused by etomidte in neonatal rats and these the abnormality lasts near two weeks.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2019.06.002","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T03:03:11Z","timestamp":1560481391000},"page":"170-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of estradiol in mediation of etomidate\u2010caused seizure\u2010like activity in neonatal rats"],"prefix":"10.1002","volume":"78","author":[{"given":"Chunyao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Psychiatry The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xihua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000358"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/527605"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06696.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318266c62d"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-2042-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04778.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2003.09.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.nbd.2014.05.010","article-title":"Sex dimorphism in seizure\u2010controlling networks","volume":"72","author":"Giorgi F.S.","year":"2014","journal-title":"Neurobiol. 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