{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:51:47Z","timestamp":1787986307049,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>Early life stress exposure, including prenatal stress (PNS), influences subsequent risk for many disorders, including substance abuse, and these effects interact with genetic factors to determine risk for disease. We previously demonstrated gene X environmental interactions across the BXD recombinant inbred mouse strain panel and their progenitor strains in PNS modulation of cocaine\u2010induced reward and locomotion. Critical to dissecting genetic interactions with PNS is consideration of the modes of stress transmission to the offspring. Both maternal neuroendocrine responses during stress and subsequent maternal\u2010offspring interactions following stress may serve as transmission modes for PNS\u2010induced changes in cocaine responsiveness. Therefore, we characterized the maternal stress response by measuring restraint stress\u2010induced plasma corticosterone (CORT) during gestation as well as effects of restraint stress on dam\u2010pup contact in the first 10 postnatal days in BXD and progenitor mouse strains. Restraint stress interacted with strain to affect plasma CORT levels and dam\u2010pup contact, indicating heritable variation of the maternal stress response. Furthermore, strain\u2010level variance in maternal stress response correlated to the impact on cocaine response exhibited by adult offspring. These findings implicate multiple modes of maternal stress response in alterations of offspring drug responsiveness and indicate that assessment of maternal endocrine and behavioral responses during early life can be utilized to dissect the complex intersection of maternal factors, the response of the offspring and genetics.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2019.06.009","type":"journal-article","created":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T14:23:41Z","timestamp":1561213421000},"page":"130-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Strain differences in maternal neuroendocrine and behavioral responses to stress and the relation to offspring cocaine responsiveness"],"prefix":"10.1002","volume":"78","author":[{"given":"Jared R.","family":"Bagley","sequence":"first","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences University of California Santa Barbara Santa Barbara CA 93106 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences University of California Santa Barbara Santa Barbara CA 93106 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel V.","family":"Bozadjian","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences University of California Santa Barbara Santa Barbara CA 93106 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Bubalo","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences University of California Santa Barbara Santa Barbara CA 93106 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tod E.","family":"Kippin","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences University of California Santa Barbara Santa Barbara CA 93106 United States"},{"name":"Neuroscience Research Institute University of California Santa Barbara Santa Barbara CA 93106 United States"},{"name":"Department of Molecular Cellular and Developmental Biology University of California Santa Barbara Santa Barbara CA 93106 United States"},{"name":"Institute for Collaborative Biotechnologies University of California Santa Barbara Santa Barbara CA 93106 United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1381.1999.09256.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1916-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301447"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.11.035"},{"key":"e_1_2_7_6_1","unstructured":"M.B.Thomas J.B.Becker.Sex differences in prenatal stress effects on cocaine pursuit in rats.Physiol. Behav.201710.1016\/j.physbeh.2017.10.019"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.02.025"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1372-5_5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","unstructured":"J.R.Bagley K.K.Szumlinski T.E.Kippin.Discovery of early life stress interacting and sex\u2010specific quantitative trait loci impacting cocaine responsiveness.Br. J. Pharmacol.2019","DOI":"10.1111\/bph.14661"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10069-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-12-03943.1996"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90073-W"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.01.017"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(98)00020-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.09.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00605-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2010.02097.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.126"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-90-1-93"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(88)90139-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.109.6.1199"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.22387"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90252-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00431-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00253-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2008.03.035"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.10.016"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(02)00491-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90262-3"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(03)00025-8"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5442.1155"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1659"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.04.012"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1169-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.101139"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.340"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.11.008"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20098"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90249-H"},{"key":"e_1_2_7_40_1","volume-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals","author":"National Research Council (US)","year":"2011"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0600473"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(91)90073-W"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.06.007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.151U049"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.05.019"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(92)90093-W"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2011.02.016"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.10.014"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110s3415"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.06.012"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11814"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420190309"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2013.07.009"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574819300668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574819300668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2019.06.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2019.06.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2019.06.009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2019.06.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:52:39Z","timestamp":1694062359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2019.06.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,22]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1016\/j.ijdevneu.2019.06.009"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2019.06.009","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,22]]},"assertion":[{"value":"2019-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}