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Previous studies have shown that repeated doses of 25\u202fmg\/kg ketamine produce schizophrenia\u2010like changes in adult male Wistar rats, but adequate doses of ketamine in animal COS studies are not yet known. Male and female Wistar rats, 23 days old, received an injection of ketamine or intraperitoneal saline (i.p.) for 8 days. The animals underwent different behavioral tests: open field, social interaction, pre\u2010pulse startle inhibition (PPI). Female rats showed behavioral changes at all ketamine doses (5, 15, 25 and 50\u202fmg\/kg), in contrast to males that only at 50\u202fmg\/kg dose had interrupted PPI and higher stereotypy in the open field test. 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