{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:08:07Z","timestamp":1791932887743,"version":"4.3.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016366","name":"General University Hospital Prague","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ijgc.2025.101768","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T01:09:04Z","timestamp":1741914544000},"page":"101768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Regression of high-grade squamous intraepithelial cervical lesions and associated risk factors (RECER)"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-4559","authenticated-orcid":false,"given":"Lukas","family":"Dostalek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Brynda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5483-855X","authenticated-orcid":false,"given":"Radim","family":"Marek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-5884","authenticated-orcid":false,"given":"Julia","family":"Hederlingova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-0398","authenticated-orcid":false,"given":"Irina","family":"Tripac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9340-9320","authenticated-orcid":false,"given":"Kristyna","family":"Nemejcova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"Slovackova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Zima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cibula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-1204","authenticated-orcid":false,"given":"Jiri","family":"Slama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ijgc.2025.101768_bib1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1056\/NEJM199802123380703","article-title":"Natural history of cervicovaginal papillomavirus infection in young women","volume":"338","author":"Ho","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.ijgc.2025.101768_bib2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/AOG.0b013e31818f5008","article-title":"Evidence for frequent regression of cervical intraepithelial neoplasia-grade 2","volume":"113","author":"Castle","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ijgc.2025.101768_bib3","article-title":"Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis","volume":"360","author":"Tainio","year":"2018","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.ijgc.2025.101768_bib4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1159\/000497286","article-title":"Spontaneous regression of cervical intraepithelial neoplasia 2: a meta-analysis","volume":"84","author":"Zhang","year":"2019","journal-title":"Gynecol Obstet Investig"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101768_bib5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00004347-199304000-00018","article-title":"Natural history of cervical intraepithelial neoplasia: a critical review","volume":"12","author":"Ost\u00f6r","year":"1993","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.ijgc.2025.101768_bib6","article-title":"Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease according to cone depth: systematic review and meta-analysis","volume":"354","author":"Kyrgiou","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.ijgc.2025.101768_bib7","unstructured":"Du\u0161ek L, Mu\u017e\u00edk J, Kub\u00e1sek M, et\u00a0al. Epidemiologie zhoubn\u00fdch n\u00e1dor\u016f v \u010cesk\u00e9 republice. Masarykovy Univerzity. Accessed March 16, 2013. https:\/\/portal.med.muni.cz\/clanek-583-epidemiologie-zhoubnych-nadoru-v-ceske-republice.html."},{"issue":"2","key":"10.1016\/j.ijgc.2025.101768_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.1866","article-title":"HPV-mediated cervical carcinogenesis: concepts and clinical implications","volume":"208","author":"Snijders","year":"2006","journal-title":"J Pathol"},{"issue":"6","key":"10.1016\/j.ijgc.2025.101768_bib9","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1097\/AOG.0b013e318237caf4","article-title":"The clinical meaning of a cervical intraepithelial neoplasia grade 1 biopsy","volume":"118","author":"Castle","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101768_bib10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/LGT.0000000000000525","article-title":"2019 ASCCP risk-based management consensus guidelines for abnormal cervical cancer screening tests and cancer precursors","volume":"24","author":"Perkins","year":"2020","journal-title":"J Low Genit Tract Dis"},{"issue":"5","key":"10.1016\/j.ijgc.2025.101768_bib11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.bpobgyn.2011.04.005","article-title":"Histology of cervical intraepithelial neoplasia and the role of biomarkers","volume":"25","author":"Martin","year":"2011","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"26","key":"10.1016\/j.ijgc.2025.101768_bib12","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1200\/JCO.21.02433","article-title":"Clinical regression of high-grade cervical intraepithelial neoplasia is associated with absence of FAM19A4\/miR124-2 DNA methylation (CONCERVE study)","volume":"40","author":"Kremer","year":"2022","journal-title":"J Clin Oncol."},{"issue":"4","key":"10.1016\/j.ijgc.2025.101768_bib13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/jcp.2010.083626","article-title":"The impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2-3","volume":"64","author":"Ovestad","year":"2011","journal-title":"J Clin Pathol"},{"issue":"1","key":"10.1016\/j.ijgc.2025.101768_bib14","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/s41467-020-15856-y","article-title":"The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions","volume":"11","author":"Mitra","year":"2020","journal-title":"Nat Commun"},{"issue":"15","key":"10.1016\/j.ijgc.2025.101768_bib15","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.3390\/cancers15153951","article-title":"Evaluation of CIN2\/3 lesion regression in GynTect\u00ae DNA methylation-marker-negative patients in a longitudinal study","volume":"15","author":"Hoyer","year":"2023","journal-title":"Cancers (Basel)"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X25008850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X25008850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T05:10:05Z","timestamp":1746767405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X25008850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S1048891X25008850"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgc.2025.101768","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regression of high-grade squamous intraepithelial cervical lesions and associated risk factors (RECER)","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijgc.2025.101768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of European Society of Gynaecological Oncology and the International Gynecologic Cancer Society.","name":"copyright","label":"Copyright"}],"article-number":"101768"}}