{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:13:37Z","timestamp":1790111617429,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.ijgc.2025.101906","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T12:06:16Z","timestamp":1745841976000},"page":"101906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic value of isolated tumor cells in sentinel lymph nodes in intermediate-risk endometrial cancer: results from an international, multi-institutional study"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8574-7346","authenticated-orcid":false,"given":"Giuseppe","family":"Cucinella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4623-470X","authenticated-orcid":false,"given":"Gabriella","family":"Schivardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun Clare","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam M.","family":"AlHilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-3796","authenticated-orcid":false,"given":"Sumer","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Covens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wohlmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-5582","authenticated-orcid":false,"given":"Glauco","family":"Baiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-864X","authenticated-orcid":false,"given":"Nedim","family":"Tokgozoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Raspagliesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7093-6862","authenticated-orcid":false,"given":"Alessandro","family":"Buda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanna","family":"Zanagnolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-7767","authenticated-orcid":false,"given":"Ignacio","family":"Zapardiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Jagasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Robert","family":"Giuntoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5233-5545","authenticated-orcid":false,"given":"Ariel","family":"Glickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Peiretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximillian","family":"Lanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Chacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Di Guilmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-1007","authenticated-orcid":false,"given":"Augusto","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-4011","authenticated-orcid":false,"given":"Enora","family":"Laas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ami","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline C.","family":"Nitschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-0128","authenticated-orcid":false,"given":"Katherine","family":"Kurnit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-4417","authenticated-orcid":false,"given":"Kristen","family":"Moriarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Joehlin-Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0551-4401","authenticated-orcid":false,"given":"Louise","family":"De Brot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagatay","family":"Taskiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Bogani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Landoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-3251","authenticated-orcid":false,"given":"Luis","family":"Chiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-0596","authenticated-orcid":false,"given":"Tommaso","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6507-2112","authenticated-orcid":false,"given":"Tommaso","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Multinu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-8666","authenticated-orcid":false,"given":"Luigi Antonio","family":"De Vitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Hernandez-Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Mastroyannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Ghoniem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6566-2502","authenticated-orcid":false,"given":"Emilia","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-3720","authenticated-orcid":false,"given":"Vito","family":"Chiantera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahi","family":"Maryam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J.","family":"Fought","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela E.","family":"McGree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-1602","authenticated-orcid":false,"given":"Andrea","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-316X","authenticated-orcid":false,"given":"Gretchen","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ijgc.2025.101906_bib1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"10.1016\/j.ijgc.2025.101906_bib2","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101906_bib3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.6004\/jnccn.2018.0006","article-title":"Uterine neoplasms, version 1.2018, NCCN Clinical Practice Guidelines in Oncology","volume":"16","author":"Koh","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"issue":"3","key":"10.1016\/j.ijgc.2025.101906_bib4","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ygyno.2014.03.019","article-title":"Impact of sentinel lymph node biopsy on the therapeutic management of early-stage endometrial cancer: results of a retrospective multicenter study","volume":"133","author":"Raimond","year":"2014","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101906_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ygyno.2011.04.030","article-title":"Sentinel lymph node mapping for endometrial cancer improves the detection of metastatic disease to regional lymph nodes","volume":"122","author":"Khoury-Collado","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"5","key":"10.1016\/j.ijgc.2025.101906_bib6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/IGC.0b013e3182954da8","article-title":"Pathologic ultrastaging improves micrometastasis detection in sentinel lymph nodes during endometrial cancer staging","volume":"23","author":"Kim","year":"2013","journal-title":"Int J Gynecol Cancer"},{"issue":"3","key":"10.1016\/j.ijgc.2025.101906_bib7","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.ygyno.2019.02.027","article-title":"Low-volume disease in endometrial cancer: the role of micrometastasis and isolated tumor cells","volume":"153","author":"Bogani","year":"2019","journal-title":"Gynecol Oncol"},{"issue":"5","key":"10.1016\/j.ijgc.2025.101906_bib8","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/ijgc-2023-005173","article-title":"Incidence of sentinel lymph node metastases in apparent early-stage endometrial cancer: a multicenter observational study","volume":"34","author":"De Vitis","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ijgc.2025.101906_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejogrb.2022.05.014","article-title":"Assessing the role of low volume disease in endometrial cancer","volume":"274","author":"Bogani","year":"2022","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"8","key":"10.1016\/j.ijgc.2025.101906_bib10","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1007\/s12094-019-02249-x","article-title":"Oncologic impact of micrometastases or isolated tumor cells in sentinel lymph nodes of patients with endometrial cancer: a meta-analysis","volume":"22","author":"G\u00f3mez-Hidalgo","year":"2020","journal-title":"Clin Transl Oncol"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101906_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ygyno.2021.04.006","article-title":"Sentinel lymph node isolated tumor cells in early staged endometrioid endometrial cancer: utility or futility?","volume":"161","author":"Sims","year":"2021","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101906_bib12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ygyno.2017.05.024","article-title":"Isolated tumor cells identified by sentinel lymph node mapping in endometrial cancer: does adjuvant treatment matter?","volume":"146","author":"Plante","year":"2017","journal-title":"Gynecol Oncol"},{"issue":"5","key":"10.1016\/j.ijgc.2025.101906_bib13","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1245\/s10434-015-5040-z","article-title":"Low-volume lymph node metastasis discovered during sentinel lymph node mapping for endometrial carcinoma","volume":"23","author":"St Clair","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101906_bib14","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ygyno.2021.02.017","article-title":"Sentinel lymph node (SLN) isolated tumor cells (ITCs) in otherwise stage I\/II endometrioid endometrial cancer: to treat or not to treat?","volume":"161","author":"Backes","year":"2021","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ijgc.2025.101906_bib15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ygyno.2021.06.031","article-title":"Oncologic outcomes of endometrial cancer in patients with low-volume metastasis in the sentinel lymph nodes: an international multi-institutional study","volume":"162","author":"Ghoniem","year":"2021","journal-title":"Gynecol Oncol"},{"issue":"7","key":"10.1016\/j.ijgc.2025.101906_bib16","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.3390\/cancers15072052","article-title":"The risk of recurrence in endometrial cancer patients with low-volume metastasis in the sentinel lymph nodes: a retrospective multi-institutional study","volume":"15","author":"Buda","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.ijgc.2025.101906_bib17","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1136\/ijgc-2023-005181","article-title":"Endometrial cancer with positive sentinel lymph nodes: pathologic characteristics of metastases as predictors of extent of lymphatic dissemination and prognosis","volume":"34","author":"Dinoi","year":"2024","journal-title":"Int J Gynecol Cancer"},{"issue":"2","key":"10.1016\/j.ijgc.2025.101906_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/ijgc-2023-005032","article-title":"Prognostic value of isolated tumor cells in sentinel lymph nodes in low risk endometrial cancer: results from an international multi-institutional study","volume":"34","author":"Cucinella","year":"2024","journal-title":"Int J Gynecol Cancer"},{"issue":"12","key":"10.1016\/j.ijgc.2025.101906_bib19","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1136\/ijgc-2021-002924","article-title":"Ultrastaging of \u2018negative\u2019 pelvic lymph nodes in patients with low- and intermediate-risk endometrioid endometrial cancer who developed non-vaginal recurrences","volume":"31","author":"Gill","year":"2021","journal-title":"Int J Gynecol Cancer"},{"issue":"5","key":"10.1016\/j.ijgc.2025.101906_bib20","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/bjc.2015.35","article-title":"Just how accurate are the major risk stratification systems for early-stage endometrial cancer?","volume":"112","author":"Bendifallah","year":"2015","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.ijgc.2025.101906_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int J Gynecol Cancer"},{"issue":"7","key":"10.1016\/j.ijgc.2025.101906_bib22","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3390\/cancers16071338","article-title":"Low-volume metastases in apparent early-stage endometrial cancer: prevalence, clinical significance, and future perspectives","volume":"16","author":"Fumagalli","year":"2024","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.ijgc.2025.101906_bib23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1136\/ijgc-2023-004981","article-title":"FIGO 2023 endometrial cancer staging: too much, too soon?","volume":"34","author":"McCluggage","year":"2024","journal-title":"Int J Gynecol Cancer"},{"issue":"10","key":"10.1016\/j.ijgc.2025.101906_bib24","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1136\/ijgc-2024-006067","article-title":"Lymphovascular space invasion in node-negative endometrial cancer: what was old is new again","volume":"34","author":"Glaser","year":"2024","journal-title":"Int J Gynecol Cancer"},{"issue":"10","key":"10.1016\/j.ijgc.2025.101906_bib25","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/ijgc-2024-005746","article-title":"Oncologic outcomes based on lymphovascular space invasion in node-negative FIGO 2009 stage I endometrioid endometrial adenocarcinoma: a multicenter retrospective cohort study","volume":"34","author":"Dagher","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ijgc.2025.101906_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ygyno.2024.06.009","article-title":"The prognostic impact of substantial lymphovascular space invasion in women with node negative FIGO stage I uterine carcinoma","volume":"188","author":"Bhatnagar","year":"2024","journal-title":"Gynecol Oncol"},{"issue":"10","key":"10.1016\/j.ijgc.2025.101906_bib27","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1136\/ijgc-2024-005672","article-title":"Impact of molecular classification on recurrence risk in endometrial cancer patients with lymph node metastasis: multicenter retrospective study","volume":"34","author":"Schivardi","year":"2024","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ijgc.2025.101906_bib28","article-title":"-\u00ad RA-\u00ad 987-\u00ad ESGOmolecular characterization of endometrial cancer with low volumemetastasis in the sentinel lymph node: a multicentric international studyinternationalstudy","volume":"32","author":"Schivardi","year":"2022","journal-title":"BMJ Specialist J"},{"key":"10.1016\/j.ijgc.2025.101906_bib29","volume":"34","author":"Hsu","year":"2024","journal-title":"BMJ Specialist Journals"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X25010254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X25010254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:38:36Z","timestamp":1782952716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X25010254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S1048891X25010254"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgc.2025.101906","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of isolated tumor cells in sentinel lymph nodes in intermediate-risk endometrial cancer: results from an international, multi-institutional study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijgc.2025.101906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 European Society of Gynaecological Oncology and the International Gynecologic Cancer Society. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101906"}}