{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T14:12:59Z","timestamp":1776348779774,"version":"3.51.2"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ijgc.2026.104602","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:11:10Z","timestamp":1770999070000},"page":"104602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of atypical extra-villous trophoblast foci on the natural history and management of post-molar gestational trophoblastic neoplasia"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-9897","authenticated-orcid":false,"given":"Sophie","family":"Schoenen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katty","family":"Delbecque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Marbaix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Christophe","family":"Noel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Delvenne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-269X","authenticated-orcid":false,"given":"Laurence","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-4486","authenticated-orcid":false,"given":"Anne-Sophie","family":"Van Rompuy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els","family":"Van Nieuwenhuysen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-721X","authenticated-orcid":false,"given":"Toon","family":"Van Gorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7589-8981","authenticated-orcid":false,"given":"Ignace","family":"Vergote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Kridelka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Adrien","family":"Bolze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Goffin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9742","key":"10.1016\/j.ijgc.2026.104602_bib1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"issue":"suppl 1","key":"10.1016\/j.ijgc.2026.104602_bib2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0020-7292(03)90120-2","article-title":"Gestational trophoblastic neoplasia, FIGO 2000 staging and classification","volume":"83","author":"Ngan","year":"2003","journal-title":"Int J Gynaecol Obstet"},{"issue":"suppl 1","key":"10.1016\/j.ijgc.2026.104602_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/ijgo.13877","article-title":"Diagnosis and management of gestational trophoblastic disease: 2021 update","volume":"155","author":"Ngan","year":"2021","journal-title":"Int J Gynaecol Obstet"},{"issue":"4","key":"10.1016\/j.ijgc.2026.104602_bib4","doi-asserted-by":"crossref","first-page":"303.e1","DOI":"10.1016\/j.ajog.2025.03.030","article-title":"Presence of atypical extravillous trophoblast foci is an independent predictor of the risk of progression to postmolar neoplasia","volume":"233","author":"Schoenen","year":"2025","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104602_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ajog.2010.06.072","article-title":"Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia","volume":"204","author":"Lurain","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104602_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijgo.2008.12.015","article-title":"Current FIGO staging for cancer of the vagina, fallopian tube, ovary, and gestational trophoblastic neoplasia","volume":"105","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"10.1016\/j.ijgc.2026.104602_bib7","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/14656566.2022.2150075","article-title":"Current chemotherapeutic options for the treatment of gestational trophoblastic disease","volume":"24","author":"Braga","year":"2023","journal-title":"Expert Opin Pharmacother"},{"issue":"5","key":"10.1016\/j.ijgc.2026.104602_bib8","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1097\/IGC.0000000000001248","article-title":"Efficacy and safety of second-line 5-day dactinomycin in case of methotrexate failure for gestational trophoblastic neoplasia","volume":"28","author":"Prouvot","year":"2018","journal-title":"Int J Gynecol Cancer"},{"issue":"9","key":"10.1016\/j.ijgc.2026.104602_bib9","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/1471-0528.16198","article-title":"Risk factors for second-line dactinomycin failure after methotrexate treatment for low-risk gestational trophoblastic neoplasia: a retrospective study","volume":"127","author":"Hoeijmakers","year":"2020","journal-title":"BJOG"},{"issue":"11","key":"10.1016\/j.ijgc.2026.104602_bib10","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1038\/bjc.2012.462","article-title":"Treatment outcomes for 618 women with gestational trophoblastic tumours following a molar pregnancy at the Charing Cross Hospital, 2000\u20132009","volume":"107","author":"Sita-Lumsden","year":"2012","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijgc.2026.104602_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ygyno.2023.11.017","article-title":"PREDICT-GTN 2: two-factor streamlined models match FIGO performance in gestational trophoblastic neoplasia","volume":"180","author":"Parker","year":"2024","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.ijgc.2026.104602_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejogrb.2020.12.001","article-title":"Curative effect of second curettage for treatment of gestational trophoblastic disease - Results of the Belgian registry for gestational trophoblastic disease","volume":"257","author":"Vandewal","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104602_bib13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000534065","article-title":"Surgical management of gestational trophoblastic disease","volume":"89","author":"Coopmans","year":"2024","journal-title":"Gynecol Obstet Investig"},{"issue":"6","key":"10.1016\/j.ijgc.2026.104602_bib14","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/ijgc-2021-003312","article-title":"Importance of pathological review of gestational trophoblastic diseases: results of the Belgian Gestational Trophoblastic Diseases Registry","volume":"32","author":"Schoenen","year":"2022","journal-title":"Int J Gynecol Cancer"},{"issue":"18","key":"10.1016\/j.ijgc.2026.104602_bib15","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1200\/JCO-24-02326","volume":"43","author":"Lok","year":"2025","journal-title":"JCO"},{"issue":"8","key":"10.1016\/j.ijgc.2026.104602_bib16","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S1470-2045(21)00262-X","article-title":"Predictors for single-agent resistance in FIGO score 5 or 6 gestational trophoblastic neoplasia: a multicentre, retrospective, cohort study","volume":"22","author":"Braga","year":"2021","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104602_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ygyno.2017.10.028","article-title":"Effectiveness and toxicity of first-line methotrexate chemotherapy in low-risk postmolar gestational trophoblastic neoplasia: the New England Trophoblastic Disease Center experience","volume":"148","author":"Maest\u00e1","year":"2018","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104602_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ygyno.2015.10.007","article-title":"Comparison of 5-day MTX and 5-day ETP treatment results and early predictors of drug resistance to 5-day MTX in patients with post-molar low-risk gestational trophoblastic neoplasia","volume":"139","author":"Kizaki","year":"2015","journal-title":"Gynecol Oncol"},{"issue":"2","key":"10.1016\/j.ijgc.2026.104602_bib19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ygyno.2016.02.014","article-title":"Postmolar choriocarcinoma: an independent risk factor for chemotherapy resistance in low-risk gestational trophoblastic neoplasia","volume":"141","author":"Strohl","year":"2016","journal-title":"Gynecol Oncol"},{"issue":"8","key":"10.1016\/j.ijgc.2026.104602_bib20","first-page":"746","article-title":"Apresenta\u00e7\u00e3o cl\u00ednica, resultados do tratamento e fatores relacionados \u00e0 resist\u00eancia em mulheres sul-americanas com neoplasia trofobl\u00e1stica gestacional p\u00f3s-molar de baixo risco","volume":"44","author":"Ram\u00edrez","year":"2022","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104602_bib21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ygyno.2012.03.039","article-title":"Treatment of nonmetastatic and metastatic low-risk gestational trophoblastic neoplasia: factors associated with resistance to single-agent methotrexate chemotherapy","volume":"125","author":"Chapman-Davis","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"8","key":"10.1016\/j.ijgc.2026.104602_bib22","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/annonc\/mdq033","article-title":"Predictive values of hCG clearance for risk of methotrexate resistance in low-risk gestational trophoblastic neoplasias","volume":"21","author":"You","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.ijgc.2026.104602_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1035170","article-title":"Monotherapy for low-risk gestational trophoblastic neoplasia with score 5\u20136","volume":"12","author":"Kemin","year":"2022","journal-title":"Front Oncol"},{"issue":"7","key":"10.1016\/j.ijgc.2026.104602_bib24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0002-9378(78)90012-1","article-title":"Gestational trophoblastic neoplasms: morphologic correlates of therapeutic response","volume":"130","author":"Deligdisch","year":"1978","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104602_bib25","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1186\/s12885-024-12758-w","article-title":"Hypermethylated RASAL1\u2019s promotive role in chemoresistance and tumorigenesis of choriocarcinoma was regulated by TET2 but not DNMTs","volume":"24","author":"Zeng","year":"2024","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104602_bib26","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ygyno.2020.05.042","article-title":"Transcriptomic and immunohistochemical approaches identify HLA-G as a predictive biomarker of gestational choriocarcinoma resistance to monochemotherapy","volume":"158","author":"Bolze","year":"2020","journal-title":"Gynecol Oncol"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X26001349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X26001349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:28:32Z","timestamp":1776346112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X26001349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1048891X26001349"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgc.2026.104602","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of atypical extra-villous trophoblast foci on the natural history and management of post-molar gestational trophoblastic neoplasia","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijgc.2026.104602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Society of Gynaecological Oncology and the International Gynecologic Cancer Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104602"}}