{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T21:44:50Z","timestamp":1785793490529,"version":"3.56.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ijgc.2026.104752","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T12:49:14Z","timestamp":1778244554000},"page":"104752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and safety of prophylactic low-dose methotrexate in high-risk hydatidiform mole for preventing post-molar gestational trophoblastic neoplasia: a prospective comparative study from Myanmar"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0692-8588","authenticated-orcid":false,"given":"Htun Lynn","family":"Soe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyi Thar","family":"Htun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myint Myint","family":"Thinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwe Mar","family":"Tun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ijgc.2026.104752_bib1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.ajog.2010.06.073","article-title":"Gestational trophoblastic disease I: Epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole","volume":"203","author":"Lurain","year":"2010","journal-title":"Am J Obstet Gynecol"},{"issue":"9742","key":"10.1016\/j.ijgc.2026.104752_bib2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"issue":"suppl 2","key":"10.1016\/j.ijgc.2026.104752_bib3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/ijgo.12615","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"143","author":"Ngan","year":"2018","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.ijgc.2026.104752_bib4","series-title":"A Tri-institutional Study of Trophoblastic Disease in Myanmar","author":"Myaing","year":"1992"},{"key":"10.1016\/j.ijgc.2026.104752_bib5","series-title":"Annual Reports on Gestational Trophoblastic Disease and Neoplasia Cases. Yangon, Myanmar","year":"2019"},{"issue":"16","key":"10.1016\/j.ijgc.2026.104752_bib6","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJMcp0900696","article-title":"Molar pregnancy","volume":"360","author":"Berkowitz","year":"2009","journal-title":"N Engl J Med."},{"issue":"3","key":"10.1016\/j.ijgc.2026.104752_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0020-7292(02)00063-2","article-title":"FIGO staging for gestational trophoblastic neoplasia 2000","volume":"77","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104752_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ygyno.2008.09.005","article-title":"Current management of gestational trophoblastic diseases","volume":"112","author":"Berkowitz","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104752_bib9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.hoc.2011.10.007","article-title":"Current management of gestational trophoblastic neoplasia","volume":"26","author":"Goldstein","year":"2012","journal-title":"Hematol Oncol Clin North Am."},{"issue":"6","key":"10.1016\/j.ijgc.2026.104752_bib10","first-page":"425","article-title":"Gestational trophoblastic disease: current evaluation and management","volume":"14","author":"Hancock","year":"2002","journal-title":"Clin Oncol (R Coll Radiol)"},{"issue":"2","key":"10.1016\/j.ijgc.2026.104752_bib11","first-page":"166","article-title":"Chemoprophylaxis in hydatidiform mole: a systematic review","volume":"115","author":"Uberti","year":"2009","journal-title":"Gynecol Oncol"},{"issue":"suppl 1","key":"10.1016\/j.ijgc.2026.104752_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0020-7292(03)90120-2","article-title":"Gestational trophoblastic neoplasia, FIGO 2000 staging and classification","volume":"83","author":"Ngan","year":"2003","journal-title":"Int J Gynecol Obstet"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104752_bib13","first-page":"e1","article-title":"Management of gestational trophoblastic disease","volume":"128","author":"Tidy","year":"2021","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104752_bib14","first-page":"123","article-title":"Postmolar gestational trophoblastic neoplasia: challenges in follow-up","volume":"135","author":"Albright","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104752_bib15","first-page":"114","article-title":"Effects of prophylactic chemotherapy for persistent gestational trophoblastic disease","volume":"71","author":"Kim","year":"1998","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104752_bib16","first-page":"355","article-title":"Prophylactic methotrexate in high-risk molar pregnancy: randomized controlled trial","volume":"136","author":"Soriano-Estrella","year":"2015","journal-title":"Gynecol Oncol"},{"issue":"9","key":"10.1016\/j.ijgc.2026.104752_bib17","first-page":"CD007289","article-title":"Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia","volume":"9","author":"Wang","year":"2017","journal-title":"Cochrane Database Syst Rev."},{"issue":"3","key":"10.1016\/j.ijgc.2026.104752_bib18","first-page":"584","article-title":"Chemoprophylaxis in gestational trophoblastic disease: controversies and perspectives","volume":"102","author":"Berkowitz","year":"2006","journal-title":"Gynecol Oncol"},{"issue":"5","key":"10.1016\/j.ijgc.2026.104752_bib19","first-page":"1231","article-title":"Toxicity profile of methotrexate in prophylactic chemotherapy","volume":"21","author":"Sharma","year":"2020","journal-title":"Asian Pac J Cancer Prev"},{"issue":"suppl 2","key":"10.1016\/j.ijgc.2026.104752_bib20","first-page":"2","article-title":"Updated FIGO recommendations for gestational trophoblastic disease","volume":"143","year":"2018","journal-title":"Int J Gynaecol Obstet"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X26002835?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X26002835?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:47:11Z","timestamp":1785790031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X26002835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1048891X26002835"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgc.2026.104752","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness and safety of prophylactic low-dose methotrexate in high-risk hydatidiform mole for preventing post-molar gestational trophoblastic neoplasia: a prospective comparative study from Myanmar","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijgc.2026.104752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 European Society of Gynaecological Oncology and the International Gynecologic Cancer Society. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104752"}}