{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:09:45Z","timestamp":1789074585103,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ijgc.2026.104760","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:27:03Z","timestamp":1778891223000},"page":"104760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical relevance of CA125 in low-grade serous ovarian cancer: a retrospective multi-center JAGO\/NOGGO study"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4429-2840","authenticated-orcid":false,"given":"Chiara","family":"Flethe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Netkova-Heintzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Postl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tasc\u00f3n Padr\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tauber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Sieghartsleitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5170-9912","authenticated-orcid":false,"given":"Maximilian","family":"Pruss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7720-8650","authenticated-orcid":false,"given":"Matthias","family":"Kohlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-8921","authenticated-orcid":false,"given":"Annette","family":"Aigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Grech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-1668","authenticated-orcid":false,"given":"Klaus","family":"Pietzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Stroisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-6623","authenticated-orcid":false,"given":"Jalid","family":"Sehouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ijgc.2026.104760_bib1","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1002\/ijc.34002","article-title":"Ovarian cancer today and tomorrow: a global assessment by world region and Human Development Index using GLOBOCAN 2020","volume":"151","author":"Cabasag","year":"2022","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104760_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ygyno.2012.06.033","article-title":"Stage at diagnosis and ovarian cancer survival: evidence from the International Cancer Benchmarking Partnership","volume":"127","author":"Maringe","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104760_bib3","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.ygyno.2019.12.033","article-title":"Low-grade serous ovarian cancer: state of the science","volume":"156","author":"Slomovitz","year":"2020","journal-title":"Gynecol Oncol"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104760_bib4","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.3802\/jgo.2018.29.e15","article-title":"Trends of low-grade serous ovarian carcinoma in the United States","volume":"29","author":"Matsuo","year":"2018","journal-title":"J Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104760_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ygyno.2016.01.022","article-title":"Operability and chemotherapy responsiveness in advanced low-grade serous ovarian cancer. An analysis of the AGO Study Group metadatabase","volume":"140","author":"Grabowski","year":"2016","journal-title":"Gynecol Oncol"},{"issue":"2 Pt 1","key":"10.1016\/j.ijgc.2026.104760_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/AOG.0b013e31829ce7ec","article-title":"Survival in women with grade 1 serous ovarian carcinoma","volume":"122","author":"Nickles Fader","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104760_bib7","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ygyno.2007.11.013","article-title":"Neoadjuvant chemotherapy for low-grade serous carcinoma of the ovary or peritoneum","volume":"108","author":"Schmeler","year":"2008","journal-title":"Gynecol Oncol"},{"issue":"23","key":"10.1016\/j.ijgc.2026.104760_bib8","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1056\/NEJMoa2103294","article-title":"Randomized trial of cytoreductive surgery for relapsed ovarian cancer","volume":"385","author":"Harter","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijgc.2026.104760_bib9","article-title":"Recent advancements in prognostic factors of epithelial ovarian carcinoma","volume":"2014","author":"Ezzati","year":"2014","journal-title":"Int Sch Res Notices"},{"issue":"15K","key":"10.1016\/j.ijgc.2026.104760_bib10","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJM198310133091503","article-title":"A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer","volume":"309","author":"Bast","year":"1983","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.ijgc.2026.104760_bib11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/bjc.1989.329","article-title":"The clinical correlates of serum CA125 in 169 patients with epithelial ovarian carcinoma","volume":"60","author":"Hawkins","year":"1989","journal-title":"Br J Cancer"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104760_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ygyno.2006.07.027","article-title":"CA125 level as a predictor of progression-free survival and overall survival in ovarian cancer patients with surgically defined disease status prior to the initiation of intraperitoneal consolidation therapy","volume":"104","author":"Juretzka","year":"2007","journal-title":"Gynecol Oncol"},{"issue":"9747","key":"10.1016\/j.ijgc.2026.104760_bib13","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(10)61268-8","article-title":"Early versus delayed treatment of relapsed ovarian cancer (MRC OV05\/EORTC 55955): a randomised trial","volume":"376","author":"Rustin","year":"2010","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.ijgc.2026.104760_bib14","first-page":"713","article-title":"Correlation of CA-125 serum level and clinico-pathological characteristic of patients with endometriosis","volume":"14","author":"Karimi-Zarchi","year":"2016","journal-title":"Int J Reprod Biomed."},{"issue":"1","key":"10.1016\/j.ijgc.2026.104760_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1741-7015-10-86","article-title":"Physiologic variations of serum tumor markers in gynecological malignancies during pregnancy: a systematic review","volume":"10","author":"Han","year":"2012","journal-title":"BMC Med"},{"key":"10.1016\/j.ijgc.2026.104760_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4103\/abr.abr_100_23","article-title":"An observational study of factors affecting CA-125 levels in premenopausal women","volume":"12","author":"Balachandran","year":"2023","journal-title":"Adv Biomed Res"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104760_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.14218\/JCTH.2017.00070","article-title":"CA-125 significance in cirrhosis and correlation with disease severity and portal hypertension: a retrospective study","volume":"6","author":"Edula","year":"2018","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.ijgc.2026.104760_bib18","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.19240","article-title":"Tumor marker elevations in chronic kidney disease: a retrospective study","volume":"13","author":"You","year":"2025","journal-title":"PeerJ"},{"key":"10.1016\/j.ijgc.2026.104760_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1161723","article-title":"Carbohydrate antigen 125 in congestive heart failure: ready for clinical application?","volume":"13","author":"Feng","year":"2023","journal-title":"Front Oncol"},{"issue":"5","key":"10.1016\/j.ijgc.2026.104760_bib20","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.pan.2020.06.009","article-title":"Elevated CA125 levels are associated with adverse clinical outcomes in acute pancreatitis: a propensity score-matched study","volume":"20","author":"Ding","year":"2020","journal-title":"Pancreatology"},{"issue":"2","key":"10.1016\/j.ijgc.2026.104760_bib26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research Electronic Data Capture (REDCap) - a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.ijgc.2026.104760_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103208","article-title":"The REDCap consortium: building an international community of software platform partners","volume":"95","author":"Harris","year":"2019","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.ijgc.2026.104760_bib28","series-title":"R: A Language and Environment for Statistical Computing","year":"2023"},{"issue":"43","key":"10.1016\/j.ijgc.2026.104760_bib29","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J Open Source Softw"},{"key":"10.1016\/j.ijgc.2026.104760_bib30","author":"Therneau"},{"key":"10.1016\/j.ijgc.2026.104760_bib31","series-title":"Modeling Survival Data: Extending the Cox Model","author":"Therneau","year":"2000"},{"key":"10.1016\/j.ijgc.2026.104760_bib32","unstructured":"Kassambara A., Kosinski M., Biecek P. survminer: drawing survival curves using ggplot2. R package. CRAN; 2021. vversion 0.4.9. Accessed January 18, 2026. https:\/\/CRAN.R-project.org\/package=survminer."},{"issue":"2","key":"10.1016\/j.ijgc.2026.104760_bib33","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ygyno.2011.01.014","article-title":"CA125 surveillance increases optimal resectability at secondary cytoreductive surgery for recurrent epithelial ovarian cancer","volume":"121","author":"Fleming","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.ijgc.2026.104760_bib24","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ygyno.2013.11.016","article-title":"The prognostic significance of pre- and post-treatment CA-125 in grade 1 serous ovarian carcinoma: a Gynecologic Oncology Group study","volume":"132","author":"Fader","year":"2014","journal-title":"Gynecol Oncol"},{"issue":"8","key":"10.1016\/j.ijgc.2026.104760_bib25","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.3390\/cancers14081954","article-title":"CA-125 levels are predictive of survival in low-grade serous ovarian cancer \u2013 a multicenter analysis","volume":"14","author":"Wohlmuth","year":"2022","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.ijgc.2026.104760_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0002-9378(86)90077-3","article-title":"The CA 125 assay as a predictor of clinical recurrence in epithelial ovarian cancer","volume":"155","author":"Niloff","year":"1986","journal-title":"Am J Obstet Gynecol"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X26002914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X26002914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:31:33Z","timestamp":1789072293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X26002914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1048891X26002914"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgc.2026.104760","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical relevance of CA125 in low-grade serous ovarian cancer: a retrospective multi-center JAGO\/NOGGO study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijgc.2026.104760","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of European Society of Gynaecological Oncology and the International Gynecologic Cancer Society.","name":"copyright","label":"Copyright"}],"article-number":"104760"}}