{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:40:52Z","timestamp":1759826452508},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,7,15]],"date-time":"2004-07-15T00:00:00Z","timestamp":1089849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p><jats:italic>Objectives<\/jats:italic>: To determine whether concentrations of \u03b2\u2010HCG in cervicovaginal secretions could predict spontaneous preterm birth (SPB) in asymptomatic high risk pregnancies. <jats:italic>Methods<\/jats:italic>: A cohort study was undertaken with cervicovaginal samples collected from 540 pregnant women between 20 to 28 weeks of gestation. Levels of \u03b2\u2010HCG were measured by ELISA test. <jats:italic>Results<\/jats:italic>: There was 3.2\u2010fold increase in cervicovaginal \u03b2\u2010HCG concentrations among patients with SPB vs. term delivery. A single cervicovaginal \u03b2\u2010HCG &gt;77.8mIU\/ml, between 20 and 28 weeks\u2019 gestation, identified patients with subsequent SPB vs. term delivery with sensitivity of 87.5% (95% CI: 47.4\u201397.9) and a specificity of 97% (95% CI: 86.5\u201399.4) with positive and negative predictive values of 88.5% and 98%, respectively. Multiple logistic regression indicates that cervicovaginal \u03b2\u2010HCG level &gt;77.8mIU\/ml was an independent predictor of SPB (adjusted odds ratio 19.97, 95% CI: 10.65\u201337.45). <jats:italic>Conclusions<\/jats:italic>: Cervicovaginal \u03b2\u2010HCG is a sensitive and specific predictor of patients with subsequent preterm delivery.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2004.05.006","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T18:24:01Z","timestamp":1093631041000},"page":"358-364","source":"Crossref","is-referenced-by-count":11,"title":["Beta\u2010human chorionic gonadotropin in cervicovaginal secretions and preterm delivery"],"prefix":"10.1002","volume":"86","author":[{"given":"A.","family":"Garshasbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ghazanfari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Faghih Zadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,15]]},"reference":[{"key":"e_1_2_5_2_2","volume-title":"Confidental enquiries into stillbirths and deaths in infancy (CESDI): 6th annual report","author":"Maternal and Child Health Consortium","year":"1999"},{"key":"e_1_2_5_3_2","first-page":"1","article-title":"Deaths: final data for 1996","volume":"47","author":"Peters K.D.","year":"1998","journal-title":"Natl Vital Stat Rep"},{"key":"e_1_2_5_4_2","first-page":"CD000065","article-title":"Prophylactic corticosteroids for preterm birth","volume":"2","author":"Crowley P.","year":"2000","journal-title":"Cochrance Database Syst Rev"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70461-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00243-6"},{"key":"e_1_2_5_7_2","first-page":"858","article-title":"Cervicovaginal fetal fibronectin as a marker for preterm delivery: a meta\u2010analysis","volume":"165","author":"Leitich H.","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90182-5"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90665-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00448-6"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70180-2"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00495-7"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729204001651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729204001651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2004.05.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2004.05.006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2004.05.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T07:35:28Z","timestamp":1696404928000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2004.05.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,15]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1016\/j.ijgo.2004.05.006"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2004.05.006","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,15]]}}}