{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:41:25Z","timestamp":1770752485864,"version":"3.50.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,12,28]],"date-time":"2004-12-28T00:00:00Z","timestamp":1104192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Within the obstetric community, several studies suggest that cervical ripening and labor induction after 40 weeks' gestation leads to improved maternal and neonatal outcomes. The most effective drug regimen to safely promote labor has not been determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Forty\u2010nine subjects followed in an outpatient obstetrical clinic with pregnancies of at least 40 weeks' gestation, and an unfavorable Bishop score were assigned randomly to receive oral misoprostol 50 or 25 \u03bcg every 3 days for a maximum of three doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three subjects received misoprostol 25 \u03bcg and 26 received 50 \u03bcg. The mean interval (\u00b1standard deviation) from start of cervical ripening to delivery was 2.4 days \u00b10.3 vs. 3.9 days \u00b10.7 for the 50 and 25 \u03bcg groups (<jats:italic>P<\/jats:italic>&lt;0.05). No adverse events were noted. However, due to small sample size, less frequent adverse events may be missed. Type II errors cannot be excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the prevention of postdate pregnancy, outpatients use of oral misoprostol 50 \u03bcg appears to result in earlier delivery, as compared to 25 \u03bcg.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2004.10.006","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T00:16:50Z","timestamp":1104365810000},"page":"108-111","source":"Crossref","is-referenced-by-count":23,"title":["Use of misoprostol on an outpatient basis for postdate pregnancy"],"prefix":"10.1002","volume":"88","author":[{"given":"J.H.","family":"Kipikasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.D.","family":"Adair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Breen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.K.","family":"Medford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sanchez\u2010Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,12,28]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"532","volume-title":"Maternal\u2010fetal medicine","author":"Resnik R.","year":"1999"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(54)80085-0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1973.tb119574.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)81266-3"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1542\/peds.40.2.202","article-title":"Factors pertaining to prolonged pregnancy and its outcome","volume":"40","author":"Zwerdling M.A.","year":"1967","journal-title":"Pediatrics"},{"key":"e_1_2_5_7_2","first-page":"296","article-title":"Perinatal characteristics of uncomplicated post\u2010date pregnancies","volume":"69","author":"Eden R.","year":"1987","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90134-2"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91615-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80170-9"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199206113262402"},{"key":"e_1_2_5_12_2","first-page":"1445","article-title":"Cost\u2010effectiveness of induction of labor versus serial antenatal monitoring in the Canadian Multicentre Postterm Pregnancy Trial","volume":"152","author":"Goeree R.","year":"1995","journal-title":"CMAJ"},{"key":"e_1_2_5_13_2","first-page":"332","article-title":"Labor induction with the prostaglandin E1 methyl analogue misoprotsol versus oxytocin: a randomized trial","volume":"81","author":"Sanchez\u2010Ramos L.","year":"1993","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70154-6"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00072-5"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(96)02805-6"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00523-6"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)80441-3"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(96)00374-2"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00278-6"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01034-6"},{"key":"e_1_2_5_22_2","first-page":"S20","article-title":"Outpatient management of prolonged pregnancy with misoprostol (MP): a randomized, double\u2010blind, placebo\u2010controlled study, prelim data","volume":"182","author":"Ascher\u2010Walsh C.","year":"2000","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729204004333?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729204004333?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2004.10.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2004.10.006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2004.10.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:29:26Z","timestamp":1696508966000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2004.10.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,28]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["10.1016\/j.ijgo.2004.10.006"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2004.10.006","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,28]]}}}