{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:04:24Z","timestamp":1783127064814,"version":"3.54.6"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T00:00:00Z","timestamp":1116806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:italic>Objective:<\/jats:italic> To evaluate the function of the hypothalamic\u2010pituitary\u2010gonadal axis in adolescent female patients with beta\u2010thalassemia major. <jats:italic>Materials and methods:<\/jats:italic> A prospective study of the function of the hypothalamic\u2010pituitary\u2010gonadal axis function of 31 beta\u2010thalassemia major females aged between 13 and 22 years and in 12 control females aged between 12 and 22 years. All were treated at Princess Rahma Teaching Hospital, Irbid, Northern Jordan between April 2001 and April 2003. <jats:italic>Results:<\/jats:italic> Of the 31 beta\u2010thalassemia major females, 13 (41.9%) had delayed puberty. Hypothalamic\u2010pituitary\u2010ovarian axis dysfunction was found in 15 patients (48.4%). Twelve patients (38.7%) had hypogonadotropic hypogonadism and 5 (16.1%) had ovarian failure. High levels of serum ferritin were significantly higher in patients with delayed puberty. <jats:italic>Conclusion:<\/jats:italic> Pituitary and ovarian dysfunction are common problems in beta\u2010thalassemia major patients. The main possible cause is iron overload. This stresses the need for intensive and regular use of chelation therapy to prevent damage to the hypothalamic\u2010pituitary\u2010ovarian axis.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2005.03.024","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T11:44:44Z","timestamp":1117021484000},"page":"44-47","source":"Crossref","is-referenced-by-count":32,"title":["Hypothalamic\u2010pituitary\u2010gonadal function in adolescent females with beta\u2010thalassemia major"],"prefix":"10.1002","volume":"90","author":[{"given":"H.S.","family":"Al\u2010Rimawi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Jallad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.O.","family":"Amarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.R.","family":"Obeidat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"17","volume-title":"Growth and endocrine complication in thalassaemia","author":"De Sanctis V.","year":"1998"},{"key":"e_1_2_5_3_2","first-page":"259","article-title":"Growth, and puberty in thalassaemia major","volume":"16","author":"Raiola G.","year":"2003","journal-title":"J Pediatr Endocrinol Metab"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.3.170"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050711"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06222.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/45.1.23"},{"key":"e_1_2_5_8_2","first-page":"581","article-title":"Italian working group on endocrine complications in non\u2010endocrine diseases","volume":"42","author":"Multicentre study on prevalence of endocrine complications in thalassaemia major","year":"1995","journal-title":"Clin Endocrinol (oxf)"},{"key":"e_1_2_5_9_2","first-page":"255","article-title":"Morbidity and mortality patterns of thalassaemia major patients in Hong Kong: retrospective study","volume":"8","author":"Li C.K.","year":"2002","journal-title":"Hong Kong Med J"},{"key":"e_1_2_5_10_2","first-page":"124","article-title":"Beta thalassemia major in Argentina","volume":"62","author":"Torres F.A.","year":"2002","journal-title":"Medicina (B. 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