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This study investigates the levels of sFlt\u20101, VEGF, and P<jats:italic>l<\/jats:italic>GF in cerebrospinal fluid (CSF) of patients with preeclampsia and normotensive controls. Methods: CSF was collected from preeclamptic patients (<jats:italic>n<\/jats:italic> = 15) and controls (<jats:italic>n<\/jats:italic> = 7) at the time of spinal anesthesia and assayed for P<jats:italic>l<\/jats:italic>GF, sFlt\u20101, and VEGF (total and free) by specific immunoassays. Results: All sought angiogenic factors were measurable. Levels of free P<jats:italic>l<\/jats:italic>GF but not sFlt\u20101 or VEGF (total or free) were increased in CSF of preeclamptic women. There was no significant difference in the ratios of angiogenic factors in the CSF of women with preeclampsia. There was no correlation between levels of angiogenic factors and CSF cell counts or severity of symptoms. Conclusion: Elevated levels of P<jats:italic>l<\/jats:italic>GF in CSF preeclamptic women may promote vascular permeability and contribute to the hypertensive encephalopathy seen in such patients.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2005.09.004","type":"journal-article","created":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T11:13:38Z","timestamp":1129893218000},"page":"32-37","source":"Crossref","is-referenced-by-count":15,"title":["Placental growth factor in the cerebrospinal fluid of women with preeclampsia"],"prefix":"10.1002","volume":"92","author":[{"given":"N.","family":"Foyouzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.R.","family":"Norwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.C.","family":"Tsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.S.","family":"Buhimschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.A.","family":"Buhimschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_5_2_2","series-title":"Practice bulletin","volume-title":"Diagnosis and management of preeclampsia and eclampsia","author":"American College of Obstetricians and Gynecologists","year":"2002"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00135-4"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01223-0"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6966.1395"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000147365.86159.f5"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.004"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10705"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99049-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)35712-0"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.20.9267"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/08977199308991586"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.052"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.1.77"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-13-1-18"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026506011458"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.05.004"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0548"},{"key":"e_1_2_5_22_2","first-page":"379","article-title":"Hypertensive encephalopathy: findings on CT, MR imaging, and SPECT imaging in 14 cases","volume":"159","author":"Schwartz R.B.","year":"1992","journal-title":"Am J Radiol"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200006001-00008"},{"key":"e_1_2_5_24_2","first-page":"97","article-title":"Pathophysiology of the blood\u2013brain barrier breakdown","volume":"89","author":"Nag S.","year":"2003","journal-title":"Methods Mol Med"},{"key":"e_1_2_5_25_2","volume-title":"Proteomic profiling of cerebrospinal fluid (CSF) in patients with severe preeclampsia suggests subclinical micro\u2010hemorrhage with functional consequences","author":"Buhimschi I.A.","year":"2005"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.055"}],"container-title":["International Journal of Gynecology &amp; 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