{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T13:46:20Z","timestamp":1774705580079,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T00:00:00Z","timestamp":1152230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To compare sublingual with vaginal misoprostol for the induction of labor. <jats:italic>Methods:<\/jats:italic> This double\u2010blind clinical trial randomized 150 women to receive every 6\u00a0h 25\u00a0\u03bcg of sublingual misoprostol and vaginal placebo or 25\u00a0\u03bcg of vaginal misoprostol and sublingual placebo. Maternal and neonatal outcomes were analyzed and risk ratios (RRs) with 95% confidence intervals (CIs) calculated. The significance level was 5%. <jats:italic>Results:<\/jats:italic> Vaginal delivery rates were 57% in the sublingual group and 69% in the vaginal group (RR, 0.8; 95% CI, 0.6\u20131.1). There were 11 cases of fetal distress in the sublingual group and 4 cases in the vaginal group (RR, 2.7; 95% CI, 0.9\u20138.2). There were no significant differences in the number of doses needed, interval between first dose and delivery, incidence of contractility disturbances, or neonatal results. <jats:italic>Conclusion:<\/jats:italic> The administration of misoprostol 25\u00a0\u03bcg by the sublingual route was neither more effective nor safer than the same dose administered vaginally.<\/jats:p>","DOI":"10.1016\/j.ijgo.2006.04.031","type":"journal-article","created":{"date-parts":[[2006,7,8]],"date-time":"2006-07-08T11:19:48Z","timestamp":1152357588000},"page":"91-95","source":"Crossref","is-referenced-by-count":26,"title":["Sublingual vs. vaginal misoprostol for induction of labor"],"prefix":"10.1002","volume":"94","author":[{"given":"F.E.L.","family":"Feitosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.S.","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"C.A.","family":"Alencar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.R.","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"R.","family":"Passini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90194-8"},{"key":"e_1_2_6_3_2","first-page":"CD001338","article-title":"Oral misoprostol for induction of labor","volume":"2","author":"Alfirevic Z.","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_4_2","first-page":"CD000941","article-title":"Vaginal misoprostol for cervical ripening and induction of labour","volume":"1","author":"Hofmeyr G.J.","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00396-X"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01459.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.118917"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000151992.75614.8d"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000083255"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-72032005000100006"},{"issue":"4","key":"e_1_2_6_11_2","first-page":"CD004221","article-title":"Buccal or sublingual misoprostol for cervical ripening and induction of labour","volume":"18","author":"Muzonzini G.","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2915-3_5"},{"key":"e_1_2_6_13_2","unstructured":"Royal College of Obstetricians and Gynaecologists. 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