{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:27:42Z","timestamp":1772782062309,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T00:00:00Z","timestamp":1182124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: Impairment of cell\u2010mediated immunity in carcinoma of the cervix (CA CX) and cervical intraepithelial neoplasia (CIN) are reported. Contradictory reports exist on lymphocyte subpopulations associated with this disease. The present study aims to quantitatively analyze peripheral blood lymphocytes subsets in patients with CA CX and CIN. <jats:italic>Method<\/jats:italic>: Systemic T lymphocyte subsets, CD19+, CD16+ and CD56+ cells in 58 CA CX and 10 CIN patients were studied. The lymphocyte phenotypes were quantified by monoclonal antibodies (anti\u2010CD4, CD8, CD16, CD19 and CD56). <jats:italic>Result<\/jats:italic>: Significant decrease in CD4+ cell population was observed in CA CX and CIN patients as compared to controls (<jats:italic>P<\/jats:italic> \u2264 0.05). CD4+\/CD8+ ratio was observed to be less in CIN patients (<jats:italic>P<\/jats:italic> \u2264 0.001). Other lymphocyte subpopulations appeared to be comparable between the groups. <jats:italic>Conclusion<\/jats:italic>: Results indicate immunological abnormalities in invasive CA CX and CIN patients. Study on a larger patient population may provide a biomarker for early detection of this disease.<\/jats:p>","DOI":"10.1016\/j.ijgo.2007.04.011","type":"journal-article","created":{"date-parts":[[2007,6,19]],"date-time":"2007-06-19T11:09:18Z","timestamp":1182251358000},"page":"143-146","source":"Crossref","is-referenced-by-count":11,"title":["Peripheral blood lymphocyte subpopulations in patients with cervical cancer"],"prefix":"10.1002","volume":"98","author":[{"given":"S.","family":"Das","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Datta Ray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Maiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.K.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chaudhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1226"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)82888-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90159-I"},{"key":"e_1_2_6_5_2","first-page":"539","article-title":"Cancers of anogenital region in renal transplant recipients. Analysis of 65 cases","volume":"53","author":"Penn I.","year":"1988","journal-title":"Cancer"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198605000-00012"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199301000-00007"},{"key":"e_1_2_6_8_2","first-page":"251","article-title":"Human papillomavirus and lower genital neoplasia in renal transplant patients","volume":"68","author":"Halpert R.","year":"1986","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(86)90065-X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1987.tb00136.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(90)90085-C"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90023-E"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01543104"},{"key":"e_1_2_6_14_2","volume-title":"Regional Office for South\u2010East Asia, Noncommunicable diseases in South\u2010East Asia region: a profile","author":"World Health Organization (WHO)","year":"2002"},{"key":"e_1_2_6_15_2","unstructured":"Ferlay J Bray F Pisani P Parkin D.M. GLOBOCAN 2002: cancer incidence. Mortality and prevalence worldwide. IARC CancerBase No. 5 version 2.0. Lyon: IARC Press 2004."},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(80)90002-5"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(80)90011-6"},{"key":"e_1_2_6_18_2","first-page":"173","article-title":"A study of T lymphocyte population in cancer of the cervix. Effects of pelvis irradiation","volume":"22","author":"Saxena V.K.","year":"1985","journal-title":"Int J Cancer"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1994.04040279.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.1995.05060438.x"},{"key":"e_1_2_6_21_2","first-page":"167","article-title":"Interactions of human T cell subsets during the induction of cytotoxic T lymphocytes: the role of interleukins","volume":"49","author":"Solbach W.","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1987.tb02245.x"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.4049\/jimmunol.126.5.1948","article-title":"Functional analysis of human T cell subsets by monoclonal antibodies. III. Regulation of helper factor production by T cell subsets","volume":"126","author":"Thomas Y.","year":"1981","journal-title":"J Immunol"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207001956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207001956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.04.011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.04.011","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2007.04.011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:18:40Z","timestamp":1696580320000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2007.04.011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,18]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1016\/j.ijgo.2007.04.011"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2007.04.011","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,18]]}}}