{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:43:06Z","timestamp":1776980586457,"version":"3.51.4"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T00:00:00Z","timestamp":1190678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the depth of necrosis achieved using CO<jats:sub>2<\/jats:sub>\u2010 and N<jats:sub>2<\/jats:sub>O\u2010cryotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We treated 20 women with CO<jats:sub>2<\/jats:sub>\u2010cryotherapy and 20 with N<jats:sub>2<\/jats:sub>O\u2010cryotherapy 24\u00a0h prior to undergoing total hysterectomy for reasons unrelated to cervical cancer. Depth of necrosis in the ectocervix was measured on surgically removed tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean depth of necrosis for the anterior lip achieved by N<jats:sub>2<\/jats:sub>O\u2010cryotherapy was 5.3\u00a0mm compared with 3.4\u00a0mm by CO<jats:sub>2<\/jats:sub>\u2010cryotherapy (<jats:italic>P<\/jats:italic> &lt; 0.001). We found similar results for the posterior lip (5.0 vs 3.1\u00a0mm; <jats:italic>P<\/jats:italic> &lt; 0.001). N<jats:sub>2<\/jats:sub>O\u2010cryotherapy was more likely than CO<jats:sub>2<\/jats:sub>\u2010cryotherapy to achieve a depth of necrosis of \u2265 4.8\u00a0mm for the anterior lip (75% vs 15%; <jats:italic>P<\/jats:italic> &lt; 0.001) and posterior lip (60% vs 5%; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed that CO<jats:sub>2<\/jats:sub>\u2010cryotherapy may not achieve the depth of necrosis necessary to completely destroy cervical precancer and therefore may be less robust than N<jats:sub>2<\/jats:sub>O\u2010cryotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2007.07.009","type":"journal-article","created":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T14:44:20Z","timestamp":1195137860000},"page":"24-26","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of depth of necrosis achieved by CO<sub>2<\/sub>\u2010 and N<sub>2<\/sub>O\u2010cryotherapy"],"prefix":"10.1002","volume":"100","author":[{"given":"J.","family":"Mariategui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Taxa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jeronimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.E.","family":"Castle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12707-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(97)00222-1"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199811000-00001"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.06.014"},{"key":"e_1_2_5_7_2","first-page":"210","article-title":"Morphometric study of intraepithelial neoplasia of the uterine cervix","volume":"60","author":"Abdul\u2010Karim F.W.","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1979.tb00695.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01683-7"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-6-2"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207004584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207004584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.07.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.07.009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2007.07.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T11:31:36Z","timestamp":1718883096000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2007.07.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,25]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1016\/j.ijgo.2007.07.009"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2007.07.009","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,25]]}}}