{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:43:55Z","timestamp":1790786635676,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T00:00:00Z","timestamp":1193270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Missed abortion in the first trimester is characterized by the arrest of embryonic or fetal development. The cervix is closed and there is no or only slight bleeding. Ultrasound examination shows an empty gestational sac or an embryo\/fetus without cardiac activity. Based on a review of the published literature a single dose of 800\u00a0\u03bcg vaginal misoprostol may be offered as an effective, safe, and acceptable alternative to the traditional surgical treatment for this indication. Alternatively, 600\u00a0\u03bcg misoprostol can be administered sublingually. After administration of misoprostol, hospitalization is not necessary and the time to expulsion varies considerably. Bleeding may last for more than 14\u00a0days with additional days of light bleeding or spotting. The woman should be advised to contact a provider in case of heavy bleeding or signs of infection. A follow\u2010up is recommended after 1 to 2\u00a0weeks.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2007.09.008","type":"journal-article","created":{"date-parts":[[2007,10,26]],"date-time":"2007-10-26T09:58:26Z","timestamp":1193392706000},"source":"Crossref","is-referenced-by-count":35,"title":["Misoprostol to treat missed abortion in the first trimester"],"prefix":"10.1002","volume":"99","author":[{"given":"K.","family":"Gemzell\u2010Danielsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.C.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"G\u00f3mez Ponce de Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Weeks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Winikoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,25]]},"reference":[{"key":"e_1_2_11_2_2","unstructured":"Neilson J.P. Hickey M. Vazquez J.: Medical treatment for early fetal death (less than 24\u00a0weeks). Cochrane Database Syst Rev. ; 19;3:CD002253. Review."},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0004-8666.2002.00161.x"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200204000-00009"},{"issue":"4","key":"e_1_2_11_5_2","doi-asserted-by":"crossref","first-page":"20S","DOI":"10.1016\/S0029-7844(02)01707-6","article-title":"Outpatient management of missed abortion with vaginal misoprostol [abstract]","volume":"99","author":"Heard M.J.","year":"2002","journal-title":"Obstet Gynecol"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.04.016"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.07.015"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg013"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2002.00662.x"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044064"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.7.1493"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei303"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.323.7314.694a"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00115-0"},{"key":"e_1_2_11_15_2","first-page":"579","article-title":"Deferred miscarriage: effectiveness of intravaginal misoprostol versus laminaria alone [Aborto diferido: eficacia del misoprostol intravaginal versus la aplicacion de tallos de laminaria]","volume":"41","author":"Rivero\u2010Lopez E.","year":"1998","journal-title":"Prog Obstet Ginecol"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138078"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1999.tb08401.x"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38828.593125.55"},{"issue":"9057","key":"e_1_2_11_19_2","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(97)24014-6","article-title":"Fertility after a randomised trial of spontaneous abortion managed by surgical evacuation or expectant treatment","volume":"5","author":"Blohm F.","year":"1997","journal-title":"Lancet"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei216"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh049"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(96)02815-9"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.010"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.2.365"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh344"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.126205"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)81438-X"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.09.008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.09.008","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207005115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207005115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2007.09.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:24:43Z","timestamp":1695547483000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2007.09.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,25]]},"references-count":26,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1016\/j.ijgo.2007.09.008"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2007.09.008","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,25]]}}}