{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:02:02Z","timestamp":1790524922408,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2737,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Gynecology &amp; Obstetrics"],"published-print":{"date-parts":[[2008,4]]},"DOI":"10.1016\/j.ijgo.2007.10.021","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T23:04:11Z","timestamp":1204844651000},"page":"16-20","source":"Crossref","is-referenced-by-count":13,"title":["Zygote score and status 1 or 2 days after cleavage and assisted reproduction outcome"],"prefix":"10.1002","volume":"101","author":[{"given":"Cristina","family":"\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Taronger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaspar","family":"Gonz\u00e1lez de Merlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,4]]},"reference":[{"key":"10.1016\/j.ijgo.2007.10.021-BIB1|reference0005","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1093\/humrep\/14.9.2345","article-title":"Characterization of a top quality embryo, a step towards single-embryo transfer","volume":"14","author":"Van Royen","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB2|reference0010","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/humrep\/14.5.1318","article-title":"The probability of abnormal preimplantation development can be predicted by a single static observation on pronuclear stage morphology","volume":"14","author":"Tesarik","year":"1999","journal-title":"Hum Reprod"},{"issue":"(3)","key":"10.1016\/j.ijgo.2007.10.021-BIB3|reference0015","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/humupd\/dmg023","article-title":"The biological basis of non-invasive strategies for selection of human oocytes and embryos","volume":"9","author":"Scott","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB4|reference0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/humupd\/dmg021","article-title":"Selection based on morphological assessment of oocytes and embryos at different stages of preimplantation development: a review","volume":"9","author":"Ebner","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB5|reference0025","first-page":"133","article-title":"Relation of human zygotes morphology with embryo quality and implantation and pregnancy rate","volume":"22","author":"\u00c1lvarez","year":"2005","journal-title":"Rev Iberoam Fertil Reprod Hum"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB6|reference0030","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/humrep\/15.6.1396","article-title":"Embryos with high implantation potential after intracytoplasmic sperm injection can be recognized by simple, non-invasive examination of pronuclear morphology","volume":"15","author":"Tesarik","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB7|reference0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0015-0282(03)00569-7","article-title":"Pronuclear morphology evaluation with subsequent evaluation of embryo morphology significant increases implantation rates","volume":"80","author":"Nagy","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB8|reference0040","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.fertnstert.2005.04.047","article-title":"Relationship between pre-embryo pronuclear morphology (zygote score) and standard day 2 or 3 embryo morphology with regard to assisted reproductive technique outcomes","volume":"84","author":"Payne","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB9|reference0045","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.fertnstert.2005.07.1319","article-title":"Comparison of pronuclear zygote morphology and early cleavage status of zygotes as additional criteria in the selection of day 3 embryos: a randomized study","volume":"85","author":"Chen","year":"2006","journal-title":"Fertil Steril"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB10|reference0050","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/humrep\/deh125","article-title":"Zygote transfer on day 1 versus cleavage stage embryo transfer on day 3: a prospective randomized trial","volume":"19","author":"Jaroudi","year":"2004","journal-title":"Hum Reprod"},{"issue":"(6)","key":"10.1016\/j.ijgo.2007.10.021-BIB11|reference0055","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/humrep\/del013","article-title":"The limited importance of pronuclear scoring of human zygotes","volume":"21","author":"James","year":"2006","journal-title":"Human Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB12|reference0060","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-4827(90)90050-K","article-title":"Assembly of the nucleolar precursor bodies in human male pronuclei is correlated with an early RNA synthetic activity","volume":"191","author":"Tesarik","year":"1990","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB13|reference0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1530\/jrf.0.0820087","article-title":"Nucleolus organizer regions and nucleoli in peattachment bovine embryos","volume":"82","author":"King","year":"1988","journal-title":"J Reprod Fertil"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB14|reference0070","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/humupd\/4.6.842","article-title":"Chromosome abnormalities in human embryos","volume":"4","author":"Munn\u00e9","year":"1998","journal-title":"Hum Reprod Updat"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB15|reference0075","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/dbio.1994.1256","article-title":"The centrosome and its mode of inheritance: the reduction of the centrosome during gametogenesis and its restoration during fertilization","volume":"165","author":"Schatten","year":"1994","journal-title":"Dev Biol"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB16|reference0080","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/oxfordjournals.humrep.a019253","article-title":"Spermatid injection into human oocytes, Part I: laboratory techniques and special features of zygote development","volume":"11","author":"Tesarik","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB17|reference0085","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/oxfordjournals.humrep.a136296","article-title":"Morphometric characterization of normal and abnormal human zygotes","volume":"10","author":"Dieguez","year":"1994","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB18|reference0090","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/humrep\/14.2.429","article-title":"Temporal and spatial aspects of fragmentation in early human embryos: possible effects on developmental competence and association with the differential elimination of regulatory proteins from polarized domains","volume":"14","author":"Antczak","year":"1999","journal-title":"Hum Reprod"},{"issue":"(suppl 2)","key":"10.1016\/j.ijgo.2007.10.021-BIB19|reference0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/humrep\/15.suppl_2.189","article-title":"Mitochondrial distribution and function in oocytes and early embryos","volume":"15","author":"Bavister","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB20|reference0100","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1093\/humrep\/16.10.2177","article-title":"The predictive value of pronuclear morphology of zygotes in the assessment of human embryo quality","volume":"16","author":"Salumets","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB21|reference0105","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1023\/A:1016300703430","article-title":"Influence of polarization effects and pronuclei on embryo quality and implantation in a IVF program","volume":"19","author":"Stalf","year":"2002","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB22|reference0110","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1093\/humrep\/deg452","article-title":"Presence, but not type or degree of extension, of a cytoplasmic halo has a significant influence on preimplantation development and implantation behaviour","volume":"18","author":"Ebner","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB23|reference0115","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/humrep\/dei282","article-title":"Morphological scoring of human pronuclear zygotes for prediction of pregnancy outcome","volume":"21","author":"Senn","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.ijgo.2007.10.021-BIB24|reference0120","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1093\/humrep\/17.9.2402","article-title":"High outcome predictability after IVF using a combined score for zygote and embryo morphology and growth rate","volume":"17","author":"De Placido","year":"2002","journal-title":"Human Reprod"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207006935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729207006935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.10.021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2007.10.021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1016\/j.ijgo.2007.10.021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T19:01:25Z","timestamp":1557342085000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1016\/j.ijgo.2007.10.021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,4]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,4]]}},"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2007.10.021","archive":["Portico"],"relation":{},"ISSN":["0020-7292"],"issn-type":[{"value":"0020-7292","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3,4]]}}}