{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:33:31Z","timestamp":1762540411355},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T00:00:00Z","timestamp":1200960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness of cryotherapy treatment delivered by general practitioners in primary care settings, as part of a screen\u2010and\u2010treat approach for cervical cancer prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Women aged between 25 and 49 years residing in San Martin, Peru, who were positive on visual inspection screening were treated, if eligible, with cryotherapy following biopsy. At 12 months post cryotherapy treatment the participants were evaluated for treatment effectiveness and examined by visual inspection and Papanicolaou test and, if positive, referred to a gynecologist for colposcopy and biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cryotherapy treatment was performed for 1398 women; of these, 531 (38%) had a histology result of cervical intraepithelial neoplasia (CIN). Cryotherapy effectively cured CIN in 418 (88%) women, including 49 (70%) women with a baseline diagnosis of CIN 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cryotherapy is an effective treatment for cervical precancerous lesions; it can easily be administered by general practitioners in primary care settings following visual inspection screening.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2007.11.013","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T20:57:31Z","timestamp":1201208251000},"page":"172-177","source":"Crossref","is-referenced-by-count":40,"title":["Effectiveness of cryotherapy treatment for cervical intraepithelial neoplasia"],"prefix":"10.1002","volume":"101","author":[{"given":"Silvana","family":"Luciani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Jeronimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,22]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"GLOBOCAN 2002 cancer incidence, mortality and prevalence worldwide, version 2.0","author":"Ferlay J.","year":"2004"},{"key":"e_1_2_6_3_2","volume-title":"Cancer in Metropolitan Lima, 1994\u20131997","author":"Maes\u2010Heller Cancer Research Center","year":"2004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2003.09.004"},{"key":"e_1_2_6_5_2","volume-title":"Effectiveness, safety and acceptability of cryotherapy: a systematic literature review","author":"Alliance for Cervical Cancer Prevention","year":"2003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)01763-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12707-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa044278"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.17.2173"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07033-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20190"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.01.009"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.01.026"},{"key":"e_1_2_6_14_2","volume-title":"Cervical cancer prevention in Peru: lessons learned from the TATI demonstration project","author":"Luciani S.","year":"2006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603633"},{"key":"e_1_2_6_16_2","volume-title":"Cost and performance of screening tests and costs of treatment of cervical cancer: San Martin Region, Peru","author":"Gordillo A.","year":"2005"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmwh.2005.04.004"},{"key":"e_1_2_6_18_2","article-title":"Comparison of depth of necrosis achieved by CO2\u2010 and N2O\u2010cryotherapy","author":"Mariategui J.","year":"2007","journal-title":"Int J Gynecol Obstet"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.06.014"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22757"}],"container-title":["International Journal of Gynecology &amp; 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