{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:59:59Z","timestamp":1792425599582,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,4,8]],"date-time":"2008-04-08T00:00:00Z","timestamp":1207612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Objective:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>To evaluate the effect of soy isoflavones on menopausal symptoms in women who do and who do not produce equol, a daidzein metabolite.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Method:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>A randomized, double\u2010blind, placebo\u2010controlled clinical trial was conducted over 6\u00a0months with 96 healthy menopausal women. After taking take 135\u00a0mg of isoflavones daily for 1\u00a0week, the women in the study group were assigned to the equol\u2010producing (EP) or the non\u2010EP group according to the presence or absence of equol in their urine. Menopausal symptoms were evaluated using a modified Kupperman Index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Result:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Compared with the placebo group, the scores for hot flashes and excessive sweating were significantly reduced after 3\u00a0months, and the scores for weakness, palpitations, limb paresthesia, and total symptoms after 6\u00a0months, in the EP group only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Conclusions:<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Isoflavone supplementation improves menopausal symptoms only in women with the ability to produce equol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.01.028","type":"journal-article","created":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T09:30:37Z","timestamp":1207733437000},"page":"44-49","source":"Crossref","is-referenced-by-count":73,"title":["Effect of intestinal production of equol on menopausal symptoms in women treated with soy isoflavones"],"prefix":"10.1002","volume":"102","author":[{"given":"Hei\u2010Jen","family":"Jou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiao\u2010Chi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Ying","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kung Shen","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Huey","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"CD002978","article-title":"Oral oestrogen and combined oestrogen\/progestogen therapy versus placebo for hot flushes","volume":"4","author":"Maclennan A.H.","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000179047.00748.53"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.8.790"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.12.3577"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC3601_5"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyh015"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3180305299"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.6.1260"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.5.1347"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.5.463"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-217-44231"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb30316.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200209000-00005"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200007020-00006"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/cmt.4.1.58.74"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000108177.85442.71"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200203000-00005"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2006.03.008"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(03)00219-6"}],"container-title":["International Journal of Gynecology &amp; 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