{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T07:48:39Z","timestamp":1759564119313},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title><jats:italic>Objective<\/jats:italic><\/jats:title><jats:p>To further the understanding of the mechanism behind myoma necrosis and uterus survival after uterine artery occlusion.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Method<\/jats:italic><\/jats:title><jats:p>Myomal and myometrial gene transcription and protein expression of tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), and plasminogen activator inhibitor type 1 (PAI\u20101) were investigated in 30 uteri.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Results<\/jats:italic><\/jats:title><jats:p>Compared with myometrial expression, myomal expression was less for uPA mRNA (1.34% \u00b1 2.18% vs 2.84% \u00b1 2.97%; <jats:italic>P<\/jats:italic> &lt; 0.05) and greater for PAI\u20101 mRNA (2.67% \u00b1 1.82% vs 1.27% \u00b1 1.99%; <jats:italic>P<\/jats:italic> &lt; 0.05), but the difference in tPA mRNA expression was not significant. Accordingly, compared with myometrial expression, myomal expression was less for the uPA protein (<jats:italic>P<\/jats:italic> &lt; 0.05) and greater for the PAI\u20101 protein (<jats:italic>P<\/jats:italic> &lt; 0.05), but the difference in tPA protein was not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title><jats:italic>Conclusion<\/jats:italic><\/jats:title><jats:p>The PA\/PAI system was found to be expressed differently in myomas and the myometrium, which may play a role in uterus survival and myoma necrosis after uterine artery occlusion.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.02.006","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T20:35:19Z","timestamp":1208464519000},"page":"55-59","source":"Crossref","is-referenced-by-count":14,"title":["Unequal tissue expression of proteins from the PA\/PAI system, myoma necrosis, and uterus survival after uterine artery occlusion"],"prefix":"10.1002","volume":"102","author":[{"given":"Zhongping","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03622-9"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112063"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200106000-00024"},{"key":"e_1_2_5_5_2","first-page":"45","article-title":"Value of preoperative embolization of uterine fibroma: report of a multicenter series of 31 cases","volume":"23","author":"Ravina J.H.","year":"1995","journal-title":"Contracept Fertil Sex"},{"key":"e_1_2_5_6_2","first-page":"S1","article-title":"Uterine artery occlusion by embolization or surgery for the treatment of fibroids: a unifying hypothesis\u2010transient uterine ischemia","volume":"7","author":"Burbank F.","year":"2000","journal-title":"J Am Assoc Gynecol Laparosc"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.12.011"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2006.00351.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)60131-4"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00910-4"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-3804(05)60189-2"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000086540.44800.FE"},{"issue":"4","key":"e_1_2_5_13_2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1160\/TH05-01-0054","article-title":"Plasminogen activation and cancer","volume":"93","author":"Dano K.","year":"2005","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1160\/TH04-03-0142","article-title":"Seminal clotting and fibrinolytic balance: a possible physiological role in the male reproductive system","volume":"92","author":"Lwaleed B.A.","year":"2004","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1055\/s-0037-1615846","article-title":"Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the uPA\u2013uPAR\u2013PAI\u20101 system","volume":"82","author":"Blasi F.","year":"1999","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422406"}],"container-title":["International Journal of Gynecology &amp; 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