{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:40:02Z","timestamp":1770982802393,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T00:00:00Z","timestamp":1216166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:italic>Objectives:<\/jats:italic> To investigate the effects of treatment with medroxyprogesterone acetate (MPA), 10\u00a0days per month for 6\u00a0months, on lipid and carbohydrate metabolism in women with polycystic ovary syndrome (PCOS). <jats:italic>Methods:<\/jats:italic> Sixty\u2010three women with PCOS were randomized to receive MPA or ethinyl estradiol plus drospirenone. <jats:italic>Results:<\/jats:italic> There were no changes in lipid or carbohydrate metabolism in the MPA group, but serum levels of luteinizing hormone (<jats:italic>P<\/jats:italic> &lt; 0.001) and total testosterone (<jats:italic>P<\/jats:italic> &lt; 0.003) significantly decreased, as did the free androgen index (<jats:italic>P<\/jats:italic> &lt; 0.02) and acne (<jats:italic>P<\/jats:italic> &lt; 0.03) and seborrhea (<jats:italic>P<\/jats:italic> &lt; 0.04) scores. In the ethinyl estradiol plus drospirenone group lipid and hormone values significantly increased whereas acne, seborrhea, hair loss, and Ferriman\u2010Gallwey scores decreased. There was no statistically significant change in the total cholesterol to high\u2010density cholesterol ratio in either group. <jats:italic>Conclusion:<\/jats:italic> Treatment of PCOS patients with MPA provided good menstrual cycle control, beneficial changes in hormonal values associated with hyperandrogenism, and no significant changes in lipid or carbohydrate metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.05.017","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T21:01:35Z","timestamp":1216328495000},"page":"44-49","source":"Crossref","is-referenced-by-count":29,"title":["Clinical and metabolic effects of medroxyprogesterone acetate and ethinyl estradiol plus drospirenone in women with polycystic ovary syndrome"],"prefix":"10.1002","volume":"103","author":[{"given":"Suna","family":"\u00d6zdemir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"G\u00f6rkemli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazim","family":"Gezgin\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysel","family":"Kiyici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041536"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.04.005"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000104485.44999.C6"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31802f35a0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3282f10e22"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13625180600983082"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031158"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1783\/1471189041261636"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57181-7"},{"issue":"3","key":"e_1_2_5_11_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jama.1995.03520270033028","article-title":"Effects of estrogen or estrogen\/progestin regimens on heart disease risk factors in postmenopausal women","volume":"273","author":"The Writing Group for the Postmenopausal Estrogen\/Progestin Interventions (PEPI) Trial","year":"1995","journal-title":"JAMA"},{"issue":"1","key":"e_1_2_5_12_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome","volume":"81","author":"The Rotterdam ESHRE\/ASRM\u2010Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92552-8"},{"key":"e_1_2_5_14_2","volume-title":"Medical eligibility criteria for initiating and continuing use of contraceptive methods","author":"World Health Organization","year":"2000"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.06.035"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(81)90746-8"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/13625180400007751"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(96)00006-6"},{"issue":"11","key":"e_1_2_5_19_2","first-page":"3327","article-title":"Metabolic effects of oral contraceptives in women with polycystic ovary syndrome","volume":"80","author":"Korytkowski M.T.","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1999.08108.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016349409013457"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020294"},{"key":"e_1_2_5_23_2","first-page":"873","volume-title":"Clinical Gynecologic Endocrinology and Infertility","author":"Speroff L.","year":"1999"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198605000-00019"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.02.004"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.1311"}],"container-title":["International Journal of Gynecology &amp; 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