{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:46:33Z","timestamp":1771530393221,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness and safety of the loop electrosurgical excision procedure (LEEP) to treat cervical intraepithelial neoplasia (CIN) in a low\u2010resource setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women participating in a cervical screening study in India with histologically confirmed CIN unsuitable for cryotherapy were advised to undergo LEEP. One year after treatment the cervix was visually inspected with acetic acid, followed by colposcopy and biopsy taken from abnormal areas. Cure was defined as no clinical or histologic evidence of CIN. Factors influencing cure rates were evaluated by <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/ijgo105-math-0001.png\" xlink:title=\"urn:x-wiley:00207292:ijgo105:equation:ijgo105-math-0001\"\/> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 311 women who underwent LEEP, 283 reported for 1\u2010year follow\u2010up and 248 (87.6%) were disease free. Cure rates were 93.0% for CIN 1, 85.5% for CIN 2, and 72.7% for CIN 3. Minor adverse effects were observed in 34 women and complications were seen in 5 women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>LEEP was associated with minimal complications and acceptable cure rates in a low\u2010resource setting, although women with larger lesions had lower cure rates.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.06.020","type":"journal-article","created":{"date-parts":[[2008,8,30]],"date-time":"2008-08-30T08:34:02Z","timestamp":1220085242000},"page":"105-110","source":"Crossref","is-referenced-by-count":32,"title":["Effectiveness and safety of loop electrosurgical excision procedure in a low\u2010resource setting"],"prefix":"10.1002","volume":"103","author":[{"given":"Prabhakaran","family":"Rema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sambasivan","family":"Suchetha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somanathan","family":"Thara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marie","family":"Fayette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramani","family":"Wesley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rengaswamy","family":"Sankaranarayanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"issue":"2","key":"e_1_2_6_2_2","first-page":"CD001318","article-title":"Surgery for cervical intraepithelial neoplasia","author":"Martin\u2010Hirsch P.L.","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1989.tb03380.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6741.1690"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91746-W"},{"issue":"2","key":"e_1_2_6_6_2","first-page":"173","article-title":"Treatment of cervical intraepithelial neoplasia using the loop electrosurgical excision procedure","volume":"79","author":"Wright T.C.","year":"1992","journal-title":"Obstet Gynecol"},{"issue":"4","key":"e_1_2_6_7_2","first-page":"337","article-title":"Electrosurgical loop excision of the cervical transformation zone: the experience of family physicians","volume":"41","author":"Ferris D.G.","year":"1995","journal-title":"J Fam Pract"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)90035-6"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1996.0088"},{"key":"e_1_2_6_10_2","volume-title":"Colposcopy and treatment of cervical intraepithelial neoplasia: A beginners' manual","author":"Sellors J.","year":"2003"},{"key":"e_1_2_6_11_2","unstructured":"Alliance for Cervical Cancer Prevention. Effectiveness safety and acceptability of cryotherapy: a systematic literature review. Cervical Cancer Prevention Issues in Depth No. 1. January 2003. Available at:http:\/\/www.path.org\/files\/RH_cryo_white_paper.pdf."},{"key":"e_1_2_6_12_2","volume-title":"IARC Handbooks on Cancer Prevention. Volume 10. Cervix Cancer Screening","year":"2004"},{"issue":"10","key":"e_1_2_6_13_2","first-page":"954","article-title":"Effective screening programmes for cervical cancer in low\u2010 and middle\u2010income developing countries","volume":"79","author":"Sankaranarayanan R.","year":"2001","journal-title":"Bull World Health Organ"},{"issue":"11","key":"e_1_2_6_14_2","first-page":"694","article-title":"Comparison of the grade of CIN in colposcopically directed biopsies with that in outpatient loop electrosurgical excision procedure (LEEP) specimens\u2013a retrospective review","volume":"40","author":"Lee K.E.","year":"1999","journal-title":"Singap Med J"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb15401.x"},{"issue":"6","key":"e_1_2_6_16_2","first-page":"1020","article-title":"Loop electrosurgical excision procedure of the transformation zone and colposcopically directed punch biopsy in the diagnosis of cervical lesions","volume":"80","author":"Bonardi R.","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1991.tb10376.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.03.036"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.044"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0845"},{"issue":"1","key":"e_1_2_6_21_2","first-page":"47","article-title":"Outpatient procedures for cervical dysplasia: a 3 year review of laser vaporisation and LEEP","volume":"54","author":"Lee K.E.","year":"1999","journal-title":"Med J Malays"},{"issue":"5","key":"e_1_2_6_22_2","first-page":"583","article-title":"Complications of loop electrosurgical excision procedure for cervical neoplasia: a prospective study","volume":"89","author":"Kietpeerakool C.","year":"2006","journal-title":"J Med Assoc Thail"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729208003056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729208003056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2008.06.020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2008.06.020","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2008.06.020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:02:43Z","timestamp":1696604563000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2008.06.020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,29]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1016\/j.ijgo.2008.06.020"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2008.06.020","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,29]]}}}