{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:55:40Z","timestamp":1774731340208,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,23]],"date-time":"2008-09-23T00:00:00Z","timestamp":1222128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of estrogen and progesterone on sleep in postmenopausal women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The 33 participants were randomly assigned to an estrogen or placebo group after undergoing clinical and hormonal assessments and a polysomnogram, and they underwent the same tests again after 12 weeks. Then, while still taking estrogen or placebo, they all received progesterone for another 12 weeks and underwent a final polysomnogram.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estrogen plus progesterone was more effective than estrogen alone in decreasing the prevalence of periodic limb movement (PLM) (8.1% vs 2.8%), hot flashes (14.2% vs 0%), and bruxism (11.1% vs 0%) at night, or somnolence and attention difficulty during the day. The prevalences of breathing irregularities, arousal from sleep, anxiety, and memory impairment were decreased in both groups following progesterone treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While not significantly affecting sleep quality, hormone therapy decreased the prevalence of arousal in both groups and that of PLM in the group treated with estrogen plus progesterone.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.07.009","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T08:55:28Z","timestamp":1222246528000},"page":"207-212","source":"Crossref","is-referenced-by-count":75,"title":["Effects of hormone therapy with estrogen and\/or progesterone on sleep pattern in postmenopausal women"],"prefix":"10.1002","volume":"103","author":[{"given":"Helena","family":"Hachul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lia R.A.","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica L.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro A.","family":"Haidar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund C.","family":"Baracat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/152460900318605"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(97)00126-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/17.6.497"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00099401"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/26.6.667"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000172270.70690.5e"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986706779026200"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(02)00208-2"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042192-200101000-00004"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1959.03010300001001"},{"key":"e_1_2_6_12_2","first-page":"338","volume-title":"Principles and Practice of Sleep Medicine","author":"Kryger M.H.","year":"2005"},{"issue":"11","key":"e_1_2_6_13_2","first-page":"505","article-title":"Sleep habits and complaints of adults in the city of S\u00e3o Paulo, Brazil, in 1987 and 1995","volume":"40","author":"Pires M.L.N.","year":"2007","journal-title":"Braz J Med Biol Res"},{"key":"e_1_2_6_14_2","volume-title":"A manual of standardized technology techniques and scoring systems for sleep stages of human subprojects","author":"Rechtschaffen A.","year":"1968"},{"issue":"5","key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep related breathing disorders in adults: recommendations for syndrome definition and measurements techniques in clinical research","volume":"22","author":"American Academy of Sleep Medicine Task Force","year":"1999","journal-title":"Sleep"},{"issue":"8","key":"e_1_2_6_16_2","first-page":"748","article-title":"Recording and scoring leg movements","volume":"16","author":"American Sleep Disorders Association (ASDA) Atlas Task Force","year":"1993","journal-title":"Sleep"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(02)00463-4"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/13697130600871947"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.12.029"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1995.tb11433.x"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.07.005"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70539-3"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0228"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.4.1656"},{"issue":"4","key":"e_1_2_6_25_2","first-page":"548","article-title":"Estrogen replacement therapy and nocturnal periodic limb movements: a randomized controlled Trial","volume":"97","author":"Polo\u2010Kantola P.","year":"2001","journal-title":"Obst Gynecol"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2007.08.009"}],"container-title":["International Journal of Gynecology &amp; 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