{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:50:43Z","timestamp":1790131843573,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T00:00:00Z","timestamp":1228953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the cost\u2010effectiveness of prenatal iron supplementation and misoprostol use as interventions to prevent maternal mortality in home births in rural India.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cost\u2010effectiveness analysis depicted three hypothetical cohorts of 10 000 pregnant women delivering at home in rural India: one with no intervention, one receiving standard prenatal iron supplements, and 1 receiving 600\u00a0\u00b5g of misoprostol in the third stage of labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Misoprostol used to prevent postpartum hemorrhage resulted in a 38% (95% CI, 5%\u201373%) decrease in maternal deaths, while prenatal iron supplementation resulted in a 5% (95% CI, 0%\u201347%) decrease. Misoprostol cost a median US $1401 (IQR US $1008\u2013$1848) prenatal iron supplementation cost a median US $2241 (IQR No Lives Saved\u2013$3882) per life saved compared with the standard care outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Misoprostol is a cost\u2010effective maternal mortality intervention for home births. Iron supplementation may be worthwhile to improve women's health, but it is uncertain whether it can prevent mortality after hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.10.011","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T09:25:39Z","timestamp":1229073939000},"page":"189-193","source":"Crossref","is-referenced-by-count":24,"title":["Cost\u2010effectiveness of misoprostol and prenatal iron supplementation as maternal mortality interventions in home births in rural India"],"prefix":"10.1002","volume":"104","author":[{"given":"Tori","family":"Sutherland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Bishai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,11]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"237","volume-title":"National family health survey (NFHS), India, 1992\u201393","author":"International Institute of Population Studies","year":"1995"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-8-6"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68397-9"},{"key":"e_1_2_6_5_2","volume-title":"Maternal Mortality in 2000: Estimates developed by WHO, UNICEF and UNFPA","author":"AbouZahr C.","year":"2003"},{"key":"e_1_2_6_6_2","volume-title":"Iron Deficiency Anemia: Assessment, Prevention and Control: A Guide for Programme Managers","author":"World Health Organization","year":"2001"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/15648265030244S206"},{"key":"e_1_2_6_8_2","volume-title":"ICMR Evaluation of the National Nutritional Anemia Prophylaxis Programme","author":"Indian Council of Medical Research","year":"1989"},{"key":"e_1_2_6_9_2","volume-title":"ICMR Field Supplementation Trial in Pregnant Women with 60\u00a0mg, 120\u00a0mg and 180\u00a0mg of Iron with 500 ug of Folic Acid","author":"Indian Council of Medical Research Task Force","year":"1992"},{"key":"e_1_2_6_10_2","volume-title":"Maternal Anemia: A Preventable Killer","author":"AED, JHPIEGO, ACCESS","year":"2006"},{"key":"e_1_2_6_11_2","volume-title":"Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attributable to Selected Major Risk Factors","author":"Stoltzfus R.J.","year":"2004"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61693-6"},{"key":"e_1_2_6_13_2","volume-title":"Coverage of Maternity Care: A Listing of the Available Information","author":"World Health Organization","year":"1997"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69522-6"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.92.2.288"},{"key":"e_1_2_6_16_2","volume-title":"National Family Health Survey (NFHS\u20102)","author":"International Institute for Population Sciences (IIPS) and ORC Macro","year":"1998"},{"issue":"9525","key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/S0140-6736(06)68805-3","article-title":"Female genital mutilation and obstetric outcome: WHO collaborative prospective study in six African countries","volume":"367","author":"WHO study group on female genital mutilation and obstetric outcome","year":"2006","journal-title":"Lancet"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","unstructured":"B.J. 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