{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:51:15Z","timestamp":1762865475865},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,12,25]],"date-time":"2008-12-25T00:00:00Z","timestamp":1230163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effectiveness of repeat loop electrosurgical excision procedure (LEEP) conization in patients with cervical intraepithelial neoplasia (CIN) grade 3 and positive ectocervical margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study of 56 women who underwent repeat LEEP conization for CIN 3 and positive ectocervical margins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Final diagnosis after repeat LEEP conization revealed 6 women (10.7%) with microinvasive squamous cell carcinoma (Stage IA1); 1 (1.8%) with CIN 1; 1 (1.8%) with CIN 2; 21 (37.5%) with CIN 3; and 27 (48.2%) with chronic cervicitis. Ectocervical or endocervical margins were negative after repeat LEEP conization in the majority of women, except for 2 patients (3.6%) with CIN 3 and positive ectocervical margins. Recurrence rate for the median follow\u2010up time of 2\u00a0years was 6.1% (3 patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeat LEEP conization can reveal undiagnosed microinvasive cervical carcinoma in women with positive ectocervical margins.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.11.015","type":"journal-article","created":{"date-parts":[[2008,12,26]],"date-time":"2008-12-26T09:25:28Z","timestamp":1230283528000},"page":"14-17","source":"Crossref","is-referenced-by-count":22,"title":["Repeat LEEP conization in patients with cervical intraepithelial neoplasia grade 3 and positive ectocervical margins"],"prefix":"10.1002","volume":"105","author":[{"given":"Ali","family":"Ayhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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