{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T13:23:09Z","timestamp":1773148989821,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,15]],"date-time":"2009-01-15T00:00:00Z","timestamp":1231977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the prevalence of human papillomavirus (HPV) infection according to cervical cytologic status in northeastern Brazil; identify other risk factors for low\u2010 and high\u2010grade squamous intraepithelial lesions (LSILs and HSILs); and identify the most prevalent HPV genotypes associated with the lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Two cervical smears were collected from 250 women referred for cancer screening, one for cytologic examination and the other to test for the presence of HPV by PCR with genotyping by dot blot hybridization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>There were 110 healthy cervices, 82 LSILs, and 58 HSILs. The overall HPV prevalence was 48%, with higher rates for HSILs, and HPV\u201016 was the most prevalent type. Age, multiple sexual partners, type of HPV present, smoking, and early onset of sexual activity were risk factors for cervical lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Age, multiple sexual partners, and infection with HPV\u201016 increased the risk of having LSILs or HSILs. Early onset of sexual activity and smoking only increased the risk of having HSILs.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.12.004","type":"journal-article","created":{"date-parts":[[2009,1,16]],"date-time":"2009-01-16T09:10:48Z","timestamp":1232097048000},"page":"21-24","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence of HPV infection by cervical cytologic status in Brazil"],"prefix":"10.1002","volume":"105","author":[{"given":"Jos\u00e9 Ver\u00edssimo","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosely","family":"de Vasconcellos Meissner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Goretti Freire","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thales Allyrio Ara\u00fajo","family":"de Medeiros Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Roberto Medeiros","family":"de Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa Lina","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11685"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.09.054"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.12.006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1258\/0956462054679214"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000204545.89516.0a"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/428779"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-36342003000900019"},{"issue":"31","key":"e_1_2_6_9_2","first-page":"29","article-title":"Chapter 3: Cofactors in human papillomavirus carcinogenesis: role of parity, oral contraceptives, and tabacco smoking","author":"Castellsague X.","year":"2003","journal-title":"J Natl Cancer Inst Monogr"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0129"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1258\/jms.2008.007061"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.05.012"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102008000300004"},{"key":"e_1_2_6_14_2","first-page":"6.28","volume-title":"Molecular cloning: a laboratory manual","author":"Sambrook J.","year":"2001"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2999980"},{"key":"e_1_2_6_16_2","first-page":"209","article-title":"The use of polymerase chain reaction amplification for the detection of genital human papillomavirus","volume":"7","author":"Manos M.M.","year":"1989","journal-title":"Cancer Cell Mol Diagnost Hum Cancer"},{"issue":"5","key":"e_1_2_6_17_2","first-page":"915","article-title":"Rapid silver staining and recovery of PCR products separated on polyacrylamide gels","volume":"17","author":"Sanguinetti C.J.","year":"1994","journal-title":"Biotechniques"},{"issue":"4","key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1128\/jcm.33.4.901-905.1995","article-title":"Group\u2010specific differentiation between high and low\u2010risk human papillomavirus genotypes by general primer\u2010mediated PCR and two cocktails of oligonucleotide probes","volume":"33","author":"Jacobs M.V.","year":"1995","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2000.00007.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67069-9"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70158-5"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(03)00218-0"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102002000100015"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-04-0812"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762003000700003"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003479"}],"container-title":["International Journal of Gynecology &amp; 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