{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:51:18Z","timestamp":1762865478665},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T00:00:00Z","timestamp":1235088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of closure or non\u2010closure of the visceral peritoneum at cesarean delivery on uterine scar formation assessed at repeat cesarean delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women undergoing initial cesarean delivery were allocated into 2 groups: group 1 underwent visceral peritoneal closure, while in group 2 the visceral peritoneum was not closed. At repeat cesarean delivery 4 specimens from the initial uterine scar were collected and assessed by light microscopy and scanning electron microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In group 1, 57% of women had adhesions compared with 20.6% in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.05). Light microscopy revealed reactive mesothelial hyperplasia (51.8% vs 13.7%), submesothelial fibrosis (48.1% vs 6.8%), and neoangiogenesis of mesothelial stroma (44.4% vs 12%) in group 1 and group 2 patients, respectively (<jats:italic>P<\/jats:italic> &lt; 0.05). Scanning electron microscopy showed more patients with pericytes on the surface of microvessels in group 1 compared with group 2 (26.3 \u00b1 1.4 vs 11.5 \u00b1 1.1 patients; <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Closure of the visceral peritoneum at cesarean delivery may produce an inflammatory reaction and adhesions, evidenced by reactive and regenerative mesothelial hyperplasia and submesothelial fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2008.12.019","type":"journal-article","created":{"date-parts":[[2009,2,22]],"date-time":"2009-02-22T07:37:17Z","timestamp":1235288237000},"page":"131-135","source":"Crossref","is-referenced-by-count":40,"title":["Effects of visceral peritoneal closure on scar formation at cesarean delivery"],"prefix":"10.1002","volume":"105","author":[{"given":"Antonio","family":"Malvasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Farine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siavash","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cavallotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Martignago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,20]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"CD004662","article-title":"Techniques for caesarean section","volume":"1","author":"Hofmeyr G.J.","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.8.1548"},{"key":"e_1_2_5_4_2","first-page":"CD000163","article-title":"Closure versus non\u2010closure of the peritoneum at caesarean section","volume":"4","author":"Bamigboye A.A.","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.03.063"},{"issue":"6","key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0015-0282(16)59942-7","article-title":"The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, m\u00fcllerian anomalies and intrauterine adhesions","volume":"49","year":"1988","journal-title":"Fertil Steril"},{"key":"e_1_2_5_7_2","first-page":"125","volume-title":"Frozen resin cracking method and its role in cytology","author":"Tanaka K.","year":"1974"},{"key":"e_1_2_5_8_2","volume-title":"Microsystems Imaging Solutions","year":"2003"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800520616"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000129342"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-002-0872-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196706000-00006"},{"issue":"2","key":"e_1_2_5_13_2","first-page":"225","article-title":"A histologic evaluation of peritoneal injury and repair: implications for adhesion formation","volume":"70","author":"Elkins T.E.","year":"1987","journal-title":"Obstet Gynecol"},{"issue":"6","key":"e_1_2_5_14_2","first-page":"1089","article-title":"Is the formation of a bladder flap at cesarean necessary? A randomized trial","volume":"98","author":"Hohlagschwandtner M.","year":"2001","journal-title":"Obstet Gynecol"},{"issue":"6","key":"e_1_2_5_15_2","first-page":"818","article-title":"A randomized study of closure of the peritoneum at cesarean delivery","volume":"77","author":"Hull D.B.","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70686-5"},{"issue":"10","key":"e_1_2_5_17_2","first-page":"1250","article-title":"Nonclosure of the visceral peritoneum during Cesarean sections","volume":"71","author":"Woyto\u0144 J.","year":"2000","journal-title":"Ginekol Pol"},{"issue":"6","key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/(SICI)1520-6661(199611\/12)5:6<366::AID-MFM15>3.0.CO;2-F","article-title":"Double\u2010layer closure of uterine incision with visceral and parietal peritoneal closure: are they obligatory steps of routine cesarean sections?","volume":"5","author":"Ohel G.","year":"1996","journal-title":"J Mater Fetal Med"},{"issue":"11","key":"e_1_2_5_19_2","first-page":"451","article-title":"Non\u2010closure of peritoneum at cesarean section. Results from repeat cesarean sections","volume":"113","author":"Nather A.","year":"2001","journal-title":"Wien Klin Wochenschr"},{"issue":"2","key":"e_1_2_5_20_2","first-page":"195","article-title":"Relationship of ultrasound findings after cesarean section to operative morbidity","volume":"66","author":"Faustin D.","year":"1985","journal-title":"Obstet Gynaecol"},{"key":"e_1_2_5_21_2","unstructured":"MahajanN.N.Justifying formation of bladder flap at cesarean section?Arch Gynecol ObstetNov 192008 [Electronic publication ahead of print]"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000149150.93552.78"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136287"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/01674820701450573"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.12.014"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198006000-00026"}],"container-title":["International Journal of Gynecology &amp; Obstetrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729209000022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0020729209000022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2008.12.019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijgo.2008.12.019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijgo.2008.12.019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:42:28Z","timestamp":1696365748000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1016\/j.ijgo.2008.12.019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,20]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["10.1016\/j.ijgo.2008.12.019"],"URL":"https:\/\/doi.org\/10.1016\/j.ijgo.2008.12.019","archive":["Portico"],"relation":{},"ISSN":["0020-7292","1879-3479"],"issn-type":[{"value":"0020-7292","type":"print"},{"value":"1879-3479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,20]]}}}