{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:29:55Z","timestamp":1773084595408,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,28]],"date-time":"2009-02-28T00:00:00Z","timestamp":1235779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the prevalence of low\u2010risk and high\u2010risk HPV genotypes in a largely suburban, non\u2010Hispanic, white female population of the USA, and to determine the positive predictive value of one\u2010occasion HPV detection and genotyping using high\u2010grade squamous intraepithelial lesion (HSIL) cytology as the endpoint for clinical evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HPV DNA present in liquid\u2010based cytology specimens collected by gynecologists in private practice was amplified using nested polymerase chain reaction. HPV DNA was validated by signature DNA sequencing for accurate genotyping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2633 specimens, 278 were positive for HPV DNA of any genotype. Among 255 single HPV infections, the most prevalent genotype was HPV\u201016 (n = 50; 19.6%), followed by HPV\u201052 (n = 24; 9.4%). Only 10 specimens, all positive for a high\u2010risk HPV, were associated with an HSIL cytology result. Among them were 6 of the 50 specimens (12%) tested positive for HPV\u201016. One novel HPV\u201039 variant was detected in repeat testing in a patient with persistent HPV infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DNA sequencing is a useful method for increasing the specificity of HPV genotyping as an aid to follow persistent high\u2010risk HPV infections to reduce excessive colposcopies in populations with low cancer prevalence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.01.019","type":"journal-article","created":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T04:21:23Z","timestamp":1235881283000},"page":"210-214","source":"Crossref","is-referenced-by-count":9,"title":["HPV infection among women in a representative rural and suburban population of the USA"],"prefix":"10.1002","volume":"105","author":[{"given":"Sin Hang","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica S.","family":"Vigliotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suri","family":"Pappu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-05-0261"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911253412201"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7364.572"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.1.46"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1428-1434.2006"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.8.813"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/426867"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818b0df2"},{"issue":"4","key":"e_1_2_6_10_2","first-page":"905","article-title":"ACOG Practice Bulletin. 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