{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:06:54Z","timestamp":1790248014918,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T00:00:00Z","timestamp":1245715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T00:00:00Z","timestamp":1245715200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp;amp; Obste"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effect of a short\u2010course pretreatment with metformin on hyperandrogenism, insulin resistance, cervical scores, and pregnancy rates in women with clomiphene citrate (CC)\u2010resistant polycystic ovary syndrome (PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010seven women with CC\u2010resistant PCOS were randomly assigned to be pretreated with 500\u00a0mg of metformin or placebo 3 times per day for 2 cycles, and 100\u00a0mg of CC was given on days 5 through 9 of the second cycle in both groups. Luteinizing hormone (LH), follicle stimulating hormone (FSH), dehydroepiandrostendione sulfate (DHEAS), total testosterone (T), glucose, and insulin levels were measured at baseline and after the first cycle, as well as body mass index (BMI), cervical score, and pregnancy rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 1 cycle, BMI, total T level, and percentage of participants with insulin resistance were significantly decreased in the metformin group, without any significant decrease in LH, FSH, and DHEAS levels; and in the second cycle, CC treatment resulted in a higher ovulation rate and a thicker endometrium in the metformin group. The pregnancy rate and cervical scores were also higher in that group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The short\u2010course pretreatment with metformin decreased hyperandrogenism and insulin resistance and improved cervical sores, ovulation rate, and pregnancy rate among women with CC\u2010resistant PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.04.022","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T10:08:30Z","timestamp":1245838110000},"page":"50-53","source":"Crossref","is-referenced-by-count":35,"title":["RETRACTED: Short\u2010term metformin treatment for clomiphene citrate\u2013resistant women with polycystic ovary syndrome"],"prefix":"10.1002","volume":"107","author":[{"given":"Talieh","family":"Kazerooni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariborz","family":"Ghaffarpasand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Kazerooni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjaneh","family":"Kazerooni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasan","family":"Setoodeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2007.07.007"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608293350902"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01499-0"},{"key":"e_1_2_5_5_2","first-page":"576","volume-title":"Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management","author":"Yen S.S.","year":"1991"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55913-5"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del053"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00502-0"},{"issue":"1","key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/gye.17.1.51.56","article-title":"Effects of metformin therapy on hyperandrogenism in women with polycystic ovary syndrome","volume":"17","author":"Kazerooni T.","year":"2003","journal-title":"Gynecol Endocrinol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02941-7"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806253382603"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.11.2700"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.8.1625"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19960730)15:14<1587::AID-SIM279>3.0.CO;2-F"},{"issue":"8","key":"e_1_2_5_15_2","first-page":"2694","article-title":"A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome","volume":"83","author":"Legro R.S.","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54541-5"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01675-7"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.04.004"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806253382603"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.289"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.12.2963"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020997"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01975-6"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)81907-3"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00341-7"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)59605-8"}],"updated-by":[{"DOI":"10.1002\/ijgo.71389","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000}}],"container-title":["International Journal of Gynecology &amp; 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