{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:56:07Z","timestamp":1774353367070,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,19]],"date-time":"2009-07-19T00:00:00Z","timestamp":1247961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of and risk factors for cervical dysplasia in HIV\u2010positive women receiving care at the Jos University Teaching Hospital in Nigeria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 369 HIV\u2010positive women had cervical cytology performed; HIV\u20101 RNA viral load and CD4 counts were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 369 participants, cervical dysplasia was present in 107 (29.0%) women. However, cervical cytology was abnormal in 252 (68.3%). Among those with abnormal cytology, 145 (57.5%) women had ASCUS, 56 (22.2%) had LSIL, and 51 (20.2%) had HSIL. Median CD4 lymphocyte count was lower in women with dysplasia compared with those without (142 vs 170 cells\/mm<jats:sup>3<\/jats:sup>; <jats:italic>P<\/jats:italic> = 0.04), while median HIV RNA viral load was higher in women with dysplasia (101 781 vs 77 479 copies\/mL; <jats:italic>P<\/jats:italic> = 0.002). Low CD4 count (&lt; 200 cells\/mm<jats:sup>3<\/jats:sup>) and evidence of HPV infection were significantly associated with cervical dysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high prevalence of cervical dysplasia was found among HIV\u2010positive Nigerian women, which was associated with increased immune suppression.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.06.006","type":"journal-article","created":{"date-parts":[[2009,7,20]],"date-time":"2009-07-20T08:11:08Z","timestamp":1248077468000},"page":"99-102","source":"Crossref","is-referenced-by-count":24,"title":["Cervical dysplasia in Nigerian women infected with HIV"],"prefix":"10.1002","volume":"107","author":[{"given":"Patricia A.","family":"Agaba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Thacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinedu C.","family":"Ekwempu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Idoko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21731"},{"issue":"7","key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1470-2045(08)70175-X","article-title":"Part I: Cancer in indigenous Africans\u2013burden, distribution and trends","volume":"9","author":"Sitas F.","year":"2008","journal-title":"Lancet Oncol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11719"},{"issue":"4","key":"e_1_2_6_5_2","first-page":"iii67","article-title":"Feminization of the HIV epidemic in the United States: major research findings and future research needs","volume":"80","author":"Wingood G.M.","year":"2003","journal-title":"J Urban Health"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.06.015"},{"key":"e_1_2_6_7_2","volume-title":"AIDS Epidemic Update: December 2007","author":"UNAIDS and WHO","year":"2007"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.07.086"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)00125-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2007.005672"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.6104"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/376996"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181744619"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610500107601"},{"issue":"2","key":"e_1_2_6_15_2","first-page":"143","article-title":"Prevalence of abnormal cervical smears among patients with HIV in Lagos, Nigeria","volume":"26","author":"Anorlu R.I.","year":"2007","journal-title":"West Afr J Med"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610310000100114"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200309050-00015"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2001.01022.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5924"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9016"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1086\/340509"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010165"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/314754"},{"issue":"1","key":"e_1_2_6_24_2","first-page":"18","article-title":"Knowledge and practice of cervical screening among female health workers in government hospitals in Abuja metropolis, Nigeria","volume":"7","author":"Olaniyan O.B.","year":"2000","journal-title":"Trop J Obstet Gynaecol"},{"issue":"4","key":"e_1_2_6_25_2","first-page":"183","article-title":"Cervical cancer and cervical cancer screening: Level of awareness in women attending a primary health care facility in Lagos, Nigeria","volume":"8","author":"Anorlu R.I.","year":"2001","journal-title":"Nig Postgrad Med J"}],"container-title":["International Journal of Gynecology &amp; 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