{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T12:47:48Z","timestamp":1709038068189},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T00:00:00Z","timestamp":1247875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness and tolerability of misoprostol to reduce the amount and duration of vaginal bleeding following surgical evacuation for first trimester spontaneous abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 160 patients who underwent surgical evacuation for first trimester spontaneous abortion between 8 and 12 weeks of pregnancy were randomized into 2 groups to receive either 200 \u00b5g of oral misoprostol immediately after evacuation followed every 6 hours for 48 hours or no misoprostol. Pain scores, duration and amount of bleeding, and endometrial thickness were assessed over 10 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women who received misoprostol had significantly fewer bleeding days after evacuation (4.11 \u00b1 2.69 vs 5.89 \u00b1 3.06; <jats:italic>P<\/jats:italic> &lt; 0.001), fewer patients reported vaginal bleeding lasting 10 days or more (3.8% vs 15.0%; <jats:italic>P<\/jats:italic> = 0.014), and endometrial thickness 10 days after evacuation was less (6.25 \u00b1 2.38 vs 7.23 \u00b1 1.94; <jats:italic>P<\/jats:italic> = 0.05). Pain scores were comparable in both groups (1.54 \u00b1 0.65 vs 1.63 \u00b1 0.83; <jats:italic>P<\/jats:italic> = 0.40) after 10 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral misoprostol is effective in reducing the prevalence and amount of vaginal bleeding after surgical evacuation for first trimester spontaneous abortion.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.06.008","type":"journal-article","created":{"date-parts":[[2009,7,19]],"date-time":"2009-07-19T08:09:45Z","timestamp":1247990985000},"page":"117-120","source":"Crossref","is-referenced-by-count":7,"title":["Oral misoprostol reduces vaginal bleeding following surgical evacuation for first trimester spontaneous abortion"],"prefix":"10.1002","volume":"107","author":[{"given":"Mahmoud","family":"Shokry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Y.","family":"Shahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed M.","family":"Fathalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar M.","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"19","volume-title":"Spontaneous Abortion: Diagnosis and Treatment","author":"Alberman E.","year":"1992"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807283190401"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200102000-00024"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.06.012"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610100202"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69522-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00711.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.10.019"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7519.723"},{"issue":"2","key":"e_1_2_6_11_2","first-page":"CD001338","article-title":"Oral misoprostol for induction of labour","volume":"19","author":"Alfirevic Z.","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1341-8076.2003.00084.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2004.00215.x"},{"issue":"2","key":"e_1_2_6_14_2","first-page":"130","article-title":"Misoprostol use as a method of medical abortion","volume":"35","author":"Salakos N.","year":"2008","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"11","key":"e_1_2_6_15_2","first-page":"1337","article-title":"Is misoprostol a safe, effective and acceptable alternative to manual vacuum aspiration for postabortion care? 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