{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:12:11Z","timestamp":1774653131751,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T00:00:00Z","timestamp":1251936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare hormone levels and clinical outcomes in patients with polycystic ovary syndrome (PCOS) after metformin therapy or laparoscopic ovarian diathermy (LOD) at 6 months follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized trial was conducted in 126 patients with PCOS who had a history of infertility for at least 1 year and resistance to clomiphene citrate (CC). Patients (n = 63) received metformin treatment or underwent LOD (n = 63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Levels of follicle\u2010stimulating hormone did not change in either group after the intervention (<jats:italic>P<\/jats:italic> &gt; 0.05). Serum levels of testosterone (<jats:italic>P<\/jats:italic> &lt; 0.001) and luteinizing hormone (<jats:italic>P<\/jats:italic> &lt; 0.001) were significantly lower after the treatment in both groups. The proportion of women with regular menstrual cycles increased significantly to 35% (<jats:italic>P<\/jats:italic> &lt; 0.001) in the LOD group and to 49% (<jats:italic>P<\/jats:italic> &lt; 0.001) in metformin group compared with before the intervention. Although proportion was higher in the metformin group compared with the LOD group, the difference was not significant (odds ratio 1.81; 95% CI, 0.88\u20133.69, <jats:italic>P<\/jats:italic> = 0.1). Hirsutism decreased significantly from 100% to 79.37% (<jats:italic>P<\/jats:italic> &lt; 0.001) in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CC\u2010resistant patients with PCOS were treated effectively by both metformin and LOD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.06.022","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T10:33:00Z","timestamp":1252060380000},"page":"236-239","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of metformin treatment and laparoscopic ovarian diathermy in patients with polycystic ovary syndrome"],"prefix":"10.1002","volume":"107","author":[{"given":"Mansoor","family":"Ashrafinia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reihaneh","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Moini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bita","family":"Eslami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Asgari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.3.556"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345663"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.04.021"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.09.010"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30642-6"},{"key":"e_1_2_6_7_2","first-page":"1086","volume-title":"Endocrine disorders","author":"Berek J.S.","year":"2007"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03225-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1993.tb15214.x"},{"key":"e_1_2_6_10_2","first-page":"465","volume-title":"Clinical Gynecologic Endocrinology and Infertility","author":"Speroff L.","year":"2005"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/01443610310000100123"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0689"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.8.2035"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)56042-7"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-992930"},{"issue":"1","key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/humrep\/den325","article-title":"Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first\u2010line method of ovulation induction in women with polycystic ovary syndrome","volume":"24","author":"Amer S.A.","year":"2009","journal-title":"Hum Reprod"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00684.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590802585605"},{"issue":"11","key":"e_1_2_6_20_2","first-page":"4278","article-title":"Correction of hyperandrogenemia by laparoscopic ovarian cautery in women with polycystic ovarian syndrome is not accompanied by improved insulin sensitivity or lipid\u2010lipoprotein levels","volume":"84","author":"Lemieux S.","year":"1999","journal-title":"J Clin Endocrinol Metab"}],"container-title":["International Journal of Gynecology &amp; 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