{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:48:53Z","timestamp":1790131733961,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,8,28]],"date-time":"2009-08-28T00:00:00Z","timestamp":1251417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV\u2010infected and uninfected women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter trial was conducted at clinical sites in 4 Sub\u2010Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV\u2010infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic\/placebo regimens were enrolled. Pregnant women were interviewed at 20\u201324 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26\u201330 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1\u2010week course was completed. Logistic regression and Cox proportional hazards models were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV\u2010infected or the uninfected cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV\u2010infected and uninfected pregnant women.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.07.037","type":"journal-article","created":{"date-parts":[[2009,8,29]],"date-time":"2009-08-29T09:25:40Z","timestamp":1251537940000},"page":"202-207","source":"Crossref","is-referenced-by-count":18,"title":["Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia"],"prefix":"10.1002","volume":"107","author":[{"given":"Said","family":"Aboud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernard","family":"Msamanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Read","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelu","family":"Mfalila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Martinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha E.","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Goldenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaie W.","family":"Fawzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,8,28]]},"reference":[{"issue":"10","key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1056\/NEJM199803053381006","article-title":"Premature rupture of the fetal membranes","volume":"338","author":"Parry S.","year":"1998","journal-title":"N Engl J Med"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-5108(18)30182-9"},{"issue":"6","key":"e_1_2_7_4_2","first-page":"1183","article-title":"Randomized clinical trial of extended antibiotic spectrum with coverage for Ureaplasma urealyticum to reduce post\u2010cesarean delivery endometritis","volume":"101","author":"Andrews W.W.","year":"2003","journal-title":"Obstet Gynecol"},{"issue":"2","key":"e_1_2_7_5_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.08.053","article-title":"Prophylactic antibiotics for the prevention of postpartum infectious morbidity in women infected with human immunodeficiency virus: a randomized controlled trial","volume":"198","author":"Sebitloane H.M.","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0029-7844(03)00172-8","article-title":"Randomized clinical trial of metronidazole plus erythromycin to prevent spontaneous preterm delivery in fetal fibronectin\u2010positive women","volume":"101","author":"Andrews W.W.","year":"2003","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.063"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600852668"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000232240.05545.08"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.004"},{"issue":"9181","key":"e_1_2_7_11_2","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0140-6736(99)80008-7","article-title":"Intrapartum and neonatal single\u2010dose nevirapine compared with zidovudine for prevention of mother\u2010to\u2010child transmission of HIV\u20101 in Kampala, Uganda: HIVNET 012 randomized trial","volume":"354","author":"Guay L.A.","year":"1999","journal-title":"Lancet"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.olq.0000216029.00424.ae"},{"issue":"12","key":"e_1_2_7_13_2","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/jama.1997.03550120049032","article-title":"Antibiotic therapy for reduction of infant morbidity after preterm premature rupture of the membranes. 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