{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:51:37Z","timestamp":1780044697150,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T00:00:00Z","timestamp":1257292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the risks and benefits of secondary cytoreductive surgery for recurrent platinum\u2010sensitive ovarian cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained retrospectively for all women with recurrent platinum\u2010sensitive epithelial ovarian cancer who underwent a second debulking operation between 1998 and 2008 at the University of Texas Southwestern Medical Center. Survival analysis and comparisons were performed using the Kaplan\u2010Meier method, log\u2010rank test, and Cox multivariate proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Optimal secondary cytoreductive surgery (&lt; 5 mm of residual disease) was achieved in 32 of 40 patients (80%). Nine women (23%) developed major complications. Two variables, residual disease of less than 5 mm vs 5 mm or greater (median 63 months vs 11 months; <jats:italic>P<\/jats:italic> = 0.003); and less than 5 vs 5 or more sites of disease relapse (median 63 months vs 22 months; <jats:italic>P<\/jats:italic> = 0.009), were independently associated with survival and retained prognostic significance on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Optimal secondary cytoreductive surgery was associated with a survival advantage and acceptable risks.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.08.034","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T12:30:55Z","timestamp":1257424255000},"page":"123-127","source":"Crossref","is-referenced-by-count":26,"title":["Secondary cytoreductive surgery for recurrent platinum\u2010sensitive ovarian cancer"],"prefix":"10.1002","volume":"108","author":[{"given":"John O.","family":"Schorge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana N.","family":"Wingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafia","family":"Bhore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Heffernan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi S.","family":"Lea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,4]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"716","volume-title":"Williams' Gynecology","author":"Schorge J.O.","year":"2008"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5926"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000192407.04428.bb"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1248"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.03.051"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.02.026"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.05.004"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.08.033"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21845"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.04.025"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22447"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/b97377"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000101)88:1<144::AID-CNCR20>3.0.CO;2-X"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20106"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-006-9273-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200206000-00011"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.08.016"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.04.006"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6404"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602466"}],"container-title":["International Journal of Gynecology &amp; 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