{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:08:13Z","timestamp":1782698893697,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of hyperandrogenism on metabolic disorders among patients with polycystic ovary syndrome (PCOS) diagnosed using the Rotterdam criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of the clinical records of 883 women with PCOS and 717 premenopausal controls identified from the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 686 (77.7%) patients were classified with PCOS based on National Institutes of Health (NIH) criteria, and 164 out of 197 (83.2%) additional patients had no hyperandrogenism. Women with normal androgen levels exhibited lower frequencies of obesity, type 2 diabetes, acanthosis nigricans, genetic history of diabetes, and elevated Matsuda index compared with hyperandrogenic patients. Hyperandrogenemia, but not hirsutism, was independently associated with the risk for type 2 diabetes (odds ratio [OR] 5.7; <jats:italic>P<\/jats:italic> = 0.028) and obesity (OR 1.7; <jats:italic>P<\/jats:italic> = 0.005) among Chinese patients with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first\u2010line management of hyperandrogenism and infertility due to PCOS.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.09.021","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T18:04:30Z","timestamp":1259345070000},"page":"148-151","source":"Crossref","is-referenced-by-count":48,"title":["Association of biochemical hyperandrogenism with type 2 diabetes and obesity in Chinese women with polycystic ovary syndrome"],"prefix":"10.1002","volume":"108","author":[{"given":"Xiaomiao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,25]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509283331307"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.149"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701536246"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02954.x"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.01.037"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den239"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.01.096"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01008.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0178"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399408000598"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1666"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000111465"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2153"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2007.12.018"},{"issue":"9","key":"e_1_2_7_17_2","first-page":"590","article-title":"Investigation of body hair assessment of Chinese women in Shandong region and its preliminary application in polycystic ovary syndrome patients","volume":"42","author":"Zhao J.L.","year":"2007","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2301"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-S055"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1327"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032046"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02764.x"},{"issue":"4","key":"e_1_2_7_23_2","first-page":"59","article-title":"Androgen physiology and the cutaneous pilosebaceous unit","volume":"3","author":"Mercurio M.G.","year":"2000","journal-title":"J Gend Specif Med"}],"container-title":["International Journal of Gynecology &amp; 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