{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:57:03Z","timestamp":1781657823013,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,6]],"date-time":"2010-01-06T00:00:00Z","timestamp":1262736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare blood loss, efficiency, and acceptability of repeated doses of sublingual misoprostol with the standard Tunisian regimen of mifepristone\u2013misoprostol for first trimester medical abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective randomized trial of 252 healthy pregnant women requesting medical abortion in the first trimester (up to 56 days). Participants were randomized to receive 200 mg of oral mifepristone followed by 400 \u00b5g of oral misoprostol (group 1) or 800 \u00b5g of sublingual misoprostol repeated every 4 hours for up to a maximum of 3 doses (group 2). Primary outcome was blood loss assessed by decrease in hematocrit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean decrease in hematocrit at follow\u2010up was significantly greater in group 1 than in group 2 (3.65% \u00b1 1.18% vs 2.69% \u00b1 1.89%, respectively; <jats:italic>P<\/jats:italic> = 0.02). There was no difference in efficiency rates between groups 1 and 2 (94.5% vs 92.1%; <jats:italic>P<\/jats:italic> = 0.7). Comparable proportions of women experiencing at least one adverse effect after misoprostol administration were reported in groups 1 and 2 (81.7% vs 79.4%; <jats:italic>P<\/jats:italic> = 0.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with the most widely used regimen in Tunisia (mifepristone\u2013misoprostol), sublingual misoprostol alone induces less blood loss (although not clinically significant); it is less expensive and offers reduced interval time to expulsion.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.11.008","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T09:16:33Z","timestamp":1262855793000},"page":"67-70","source":"Crossref","is-referenced-by-count":17,"title":["Sublingual misoprostol for first trimester termination of pregnancy"],"prefix":"10.1002","volume":"109","author":[{"given":"Myriam","family":"Fekih","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Fathallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lassad Ben","family":"Regaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sassi","family":"Bouguizane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouar","family":"Chaieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedi","family":"Khairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04563-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2003.08.019"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.06.012"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-2315(05)82744-9"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2005.02.008"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-8080(04)24010-1"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.08.018"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00134-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.6.1477"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60914-3"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.03.005"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.09.004"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305273282101"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2006.03.009"},{"issue":"1","key":"e_1_2_6_16_2","first-page":"CD002855","article-title":"Medical methods for first trimester abortion","author":"Kulier R.","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"e_1_2_6_17_2","first-page":"389","article-title":"Blood loss at time of caesarean section by method of placental removal and exteriorization versus in situ repair of the uterine incision","volume":"177","author":"Magann E.F.","year":"1993","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00354-2"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(93)90111-J"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(98)00102-7"}],"container-title":["International Journal of Gynecology &amp; 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