{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:47:44Z","timestamp":1792021664453,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,13]],"date-time":"2010-01-13T00:00:00Z","timestamp":1263340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy of rectally administered misoprostol with intravenous oxytocin infusion in preventing uterine atony and blood loss during cesarean delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, randomized, double\u2010blind trial, 200 women undergoing cesarean delivery who did not have risk factors for postpartum hemorrhage were randomly allocated to receive either 800 \u00b5g of rectal misoprostol at the time of peritoneal incision or an intravenous infusion of oxytocin after delivery of the neonate. Primary outcome measures were estimated amount of intraoperative and postoperative (8 hours) blood loss and changes in hemoglobin levels 24 hours after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 96 and 94 women were analyzed in the misoprostol and oxytocin groups, respectively. Intraoperative and postoperative blood loss was significantly lower in the misoprostol group than in the oxytocin group (503 vs 592 mL, <jats:italic>P<\/jats:italic> = 0.003 and 74 vs 114 mL, <jats:italic>P<\/jats:italic> = 0.045, respectively). The incidence of shivering was higher in the misoprostol group (8.3% vs 1.1%, <jats:italic>P<\/jats:italic> = 0.018; RR 7.83; 95% confidence interval, 0.99\u201361.42).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rectal misoprostol appears to be an effective alternative to intravenous oxytocin in preventing blood loss for routine use during cesarean delivery. Clinical Trials Registration: CTRI\/2009\/091\/000075.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2009.11.009","type":"journal-article","created":{"date-parts":[[2010,1,15]],"date-time":"2010-01-15T05:55:01Z","timestamp":1263534901000},"page":"25-29","source":"Crossref","is-referenced-by-count":35,"title":["Rectally administered misoprostol versus intravenous oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss"],"prefix":"10.1002","volume":"109","author":[{"given":"Picklu","family":"Chaudhuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita Basu","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apurba","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000163309.53317.B8"},{"issue":"1","key":"e_1_2_6_3_2","first-page":"77","article-title":"Factors associated with hemorrhage in cesarean deliveries","volume":"77","author":"Combs C.A.","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.080003245.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200109000-00005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael302"},{"key":"e_1_2_6_7_2","first-page":"CD000494","article-title":"Prostaglandins for preventing postpartum haemorrhage","author":"G\u00fclmezoglu A.M.","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00174-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.01.018"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32594-4"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)30296-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.10.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.05.031"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2001.tb01319.x"},{"issue":"7","key":"e_1_2_6_15_2","first-page":"403","article-title":"Clinical study on reduction of postpartum bleeding in cesarean section by misoprostol","volume":"33","author":"Zhao Y.","year":"1998","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.033"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.080009835.x"},{"issue":"2","key":"e_1_2_6_18_2","first-page":"5160","article-title":"Misoprostol: pharmacokinetic profiles, effects on uterus and side\u2010effects","volume":"99","author":"Tang O.S.","year":"2007","journal-title":"Int J Gynecol Obstet"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-199901000-00033"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.06.010"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.332"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(96)80016-6"}],"container-title":["International Journal of Gynecology &amp; 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