{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:11:59Z","timestamp":1787613119906,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T00:00:00Z","timestamp":1269561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effect of an oxytocin infusion alone or preceded by an intravaginal application of misoprostol for labor induction in women with term pregnancies and a low Bishop score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study randomized 100 multiparous women with singleton pregnancies over 38 weeks and a Bishop score less than 6 to receive either a single 50\u2010\u00b5g dose of misoprostol intravaginally 3 hours before initiation of the oxytocin infusion or only an oxytocin infusion. The time from induction to delivery, the route of delivery, and maternal and fetal outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean time from induction to delivery was 9.36 \u00b1 1.97 hours in the misoprostol plus oxytocin group and 11.08 \u00b1 3.23 in the oxytocin alone group (<jats:italic>P<\/jats:italic> = 0.002). The rates of vaginal delivery, 1\u2010 and 5\u2010minute Agpar scores, placental abruption, and postpartum hemorrhage were similar between the 2 groups, as were the rates of admission to the neonatal intensive care unit. There were no cases of perinatal asphyxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A 50\u2010\u00b5g intravaginal application of misoprostol before starting the oxytocin infusion is a more effective method of labor induction than an oxytocin infusion alone for our study population.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2010.02.004","type":"journal-article","created":{"date-parts":[[2010,3,27]],"date-time":"2010-03-27T08:22:46Z","timestamp":1269678166000},"page":"64-67","source":"Crossref","is-referenced-by-count":8,"title":["Induction of labor with vaginal misoprostol plus oxytocin versus oxytocin alone"],"prefix":"10.1002","volume":"110","author":[{"given":"Osman","family":"Balci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa S.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suna","family":"Ozdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Acar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.07.014"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198812000-00004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02054.x"},{"issue":"3","key":"e_1_2_6_5_2","first-page":"332","article-title":"Labor induction with the prostaglandin E1 methyl analogue misoprostol versus oxytocin: a randomized trial","volume":"81","author":"Sanchez\u2010Ramos L.","year":"1993","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.332"},{"issue":"5","key":"e_1_2_6_7_2","first-page":"659","article-title":"Labor induction with continuous low\u2010dose oxytocin infusion: a randomized trial","volume":"77","author":"Mercer B.","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00600.x"},{"key":"e_1_2_6_9_2","series-title":"Evidence\u2010based Clinical Guideline","author":"Royal College of Obstetricians and Gynaecologists","year":"2001"},{"issue":"5","key":"e_1_2_6_10_2","first-page":"1049","article-title":"New US Food and Drug Administration labeling on Cytotec (misoprostol) use and pregnancy","volume":"101","author":"American College of Obstetricians and Gynecologists","year":"2003","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.3.709"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep108"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(01)00449-0"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2005.03.010"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003246","article-title":"Intravenous oxytocin alone for cervical ripening and induction of labor","volume":"3","author":"Kelly A.J.","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.09.015"},{"issue":"4","key":"e_1_2_6_17_2","first-page":"218","article-title":"Vaginal application of misoprostol for labor induction after 36 weeks of pregnancy","volume":"61","author":"Godinjak Z.","year":"2007","journal-title":"Med Arh"},{"issue":"3","key":"e_1_2_6_18_2","first-page":"213","article-title":"Efficacy and safety of misoprostol in induction of labor in a Nigerian tertiary hospital","volume":"26","author":"Abdul M.A.","year":"2007","journal-title":"West Afr J Med"}],"container-title":["International Journal of Gynecology &amp; 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