{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:11:54Z","timestamp":1771333914065,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T00:00:00Z","timestamp":1270166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the safety and efficacy of vaginal misoprostol for second\u2010trimester abortion in women with 3 or more prior cesarean deliveries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted with 138 women who needed pregnancy termination between 13 and 26 gestational weeks, 31 with 3 or more previous cesarean deliveries and 107 with no uterine scars (the controls). Misoprostol was inserted in the vagina every 6 hours until regular contractions or products of conception appeared, a 200\u2010\u00b5g tablet for the first 24 hours and 2 tablets thereafter. The outcomes assessed were successful vaginal abortion, hemorrhage requiring blood transfusion, incomplete abortion, and uterine rupture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A vaginal abortion occurred in 28 women (90.3%) in the study group and 107 (100%) in the control group (<jats:italic>P<\/jats:italic> = 0.01). There were no significant differences in the prevalence of the other assessed outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vaginal misoprostol appears to be safe and acceptably effective for second\u2010trimester pregnancy termination in women with 3 or more previous cesarean deliveries.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2010.02.008","type":"journal-article","created":{"date-parts":[[2010,4,3]],"date-time":"2010-04-03T08:33:28Z","timestamp":1270283608000},"page":"50-52","source":"Crossref","is-referenced-by-count":24,"title":["Midtrimester abortion using vaginal misoprostol for women with three or more prior cesarean deliveries"],"prefix":"10.1002","volume":"110","author":[{"given":"Muhammad","family":"Fawzy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u2010Said","family":"Abdel\u2010Hady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,4,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408043310502"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(02)00347-8"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.09.004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)80019-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2004.00258.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000087115"},{"issue":"2","key":"e_1_2_6_8_2","first-page":"1","article-title":"Births: final data for 2001","volume":"51","author":"Martin J.A.","year":"2002","journal-title":"Natl Vital Stat Rep"},{"issue":"2","key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.26719\/2009.15.2.458","article-title":"Hospital\u2010based cesarean section in the Arab region: an overview","volume":"15","author":"Khawaja M.","year":"2009","journal-title":"East Mediterr Health J"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml049"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.05.023"},{"issue":"5","key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0029-7844(99)00335-X","article-title":"Separation of cesarean scar during second\u2010trimester intravaginal misoprostol abortion","volume":"94","author":"Chen M.","year":"1999","journal-title":"Obstet Gynecol"},{"issue":"5","key":"e_1_2_6_13_2","first-page":"976","article-title":"Uterine rupture during second\u2010trimester abortion associated with misoprostol","volume":"98","author":"Berghahn L.","year":"2001","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2009.03.009"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000151996.16422.88"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.09.007"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(80)90010-1"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000292602"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00300.x"}],"container-title":["International Journal of Gynecology &amp; 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