{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:10:25Z","timestamp":1791900625428,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T00:00:00Z","timestamp":1288656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To assess, among women with HIV, whether long\u2010term oral\n                      <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                      GR\u20101 and\n                      <jats:italic>Lactobacillus reuteri<\/jats:italic>\n                      RC\u201014 supplementation can prevent bacterial vaginosis (BV) and enhance the cure rate of metronidazole among those with BV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, double\u2010blind, placebo\u2010controlled trial conducted among 65 HIV\u2010infected women with an aberrant microbiota (Nugent score 4\u201310) who were randomized to receive daily probiotics or placebo for 6 months. Those with BV (Nugent score 7\u201310) additionally received metronidazole for 10 days (400 mg twice daily).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We did not find an enhanced cure rate of BV among women with HIV treated with adjuvant probiotics to metronidazole treatment. Among women with an intermediate vaginal flora, probiotics tended to increase the probability of a normal vaginal flora (odds ratio 2.4;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.1) and significantly increased the probability of a beneficial vaginal pH (odds ratio 3.8;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02) at follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Supplementation of probiotic\n                      <jats:italic>L. rhamnosus<\/jats:italic>\n                      GR\u20101 and\n                      <jats:italic>L. reuteri<\/jats:italic>\n                      RC\u201014 did not enhance the cure of BV among women living with HIV, but may prevent the condition among this population. Trial registration: NCT00536848.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2010.07.008","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T05:25:36Z","timestamp":1283318736000},"page":"245-248","source":"Crossref","is-referenced-by-count":74,"title":["<i>Lactobacillus rhamnosus<\/i>\n                    GR\u20101 and\n                    <i>L. reuteri<\/i>\n                    RC\u201014 to prevent or cure bacterial vaginosis among women with HIV"],"prefix":"10.1002","volume":"111","author":[{"given":"Ruben","family":"Hummelen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Changalucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicodemus L.","family":"Butamanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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