{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:53:11Z","timestamp":1767966791489,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T00:00:00Z","timestamp":1284595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the expression profiles of transforming growth factor\u2010beta 1 (TGF\u2010\u03b21) and its receptors in occluded tubes of infertile women with those of control patients and to evaluate the potential correlation with postsurgical pregnancy outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The expression profiles of TGF\u2010\u03b21, TGF\u2010\u03b21R1, and TGF\u2010\u03b21R2 in occluded fallopian tubes were compared using immunohistochemistry between 60 infertile patients with adhered tubes and 60 control patients with normal tubes; potential correlations with postsurgical fertility were evaluated at 2\u2010year follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunostainings of TGF\u2010\u03b21, TGF\u2010\u03b21R1, and TGF\u2010\u03b21R2 were all significantly elevated in patients with adhered tubes compared with normal specimens (<jats:italic>P<\/jats:italic> &lt; 0.001). In adhered specimens, correlation analyses showed positive correlations between TGF\u2010\u03b21 and TGF\u2010\u03b21R1 (<jats:italic>P<\/jats:italic> = 0.008), and TGF\u2010\u03b21 and TGF\u2010\u03b21R2 (<jats:italic>P<\/jats:italic> = 0.035). At 2\u2010year follow up, 32 of the 60 infertile women had achieved normal pregnancies, 5 had had ectopic pregnancies, and 23 remained infertile. Correlation analysis showed that TGF\u2010\u03b21 expression level was negatively correlated with pregnancy outcome (r = \u20130.445, <jats:italic>P<\/jats:italic> &lt; 0.001), independent of adhesion severity or patient age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TGF\u2010\u03b21 expression was independently correlated with the postsurgical pregnancy outcome among infertile women.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2010.07.016","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T10:03:14Z","timestamp":1284717794000},"page":"11-14","source":"Crossref","is-referenced-by-count":11,"title":["Correlation between overexpression of transforming growth factor\u2010beta 1 in occluded fallopian tubes and postsurgical pregnancy among infertile women"],"prefix":"10.1002","volume":"112","author":[{"given":"Zhengyu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjiao","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,9,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.f.1895"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082387"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199411103311907"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1995.30405.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/107155769900600307"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.113039"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475X.1997.50116.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(00)80082-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.11.1249"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23808"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.6.1291"},{"issue":"4","key":"e_1_2_6_13_2","first-page":"1177","article-title":"Human fallopian tube expressed transforming growth factor (TGF beta) isoforms, TGF beta type I\u2010III receptor messenger ribonucleic acid and protein, and contains [125I] TGF beta\u2010binding sites","volume":"79","author":"Zhao Y.","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082387"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082388"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(92)90280-D"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.12.017"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61190-X"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml061"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.04.057"}],"container-title":["International Journal of Gynecology &amp; 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