{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:16:32Z","timestamp":1786990592489,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T00:00:00Z","timestamp":1290124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the efficacy of a levonorgestrel\u2010releasing intrauterine system (LNG\u2010IUS) with that of a low\u2010dose combined oral contraceptive (COC) in reducing fibroid\u2010related menorrhagia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center, open, randomized clinical trial, 58 women with menorrhagia who desired contraception were randomized to receive a LNG\u2010IUS or COC. The outcomes included treatment failure, defined as the need for another treatment; menstrual blood loss (MBL) by the alkaline hematin method and a pictorial assessment chart (PBAC); hemoglobin levels; and \u201clost days.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Treatment failed in 6 women (23.1%) in the LNG\u2010IUS group and 11 (37.9%) in the COC group, for a hazard ratio of 0.46 (95% CI, 0.17\u20131.17,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.101). Using the alkaline hematin test, the reduction of MBL was significantly greater in the LNG\u2010IUS group (90.9% \u00b1 12.8% vs 13.4% \u00b1 11.1%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001). Using PBAC scores, the reduction was also significantly greater in the LNG\u2010IUS group (88.0% \u00b1 16.5% vs 53.5% \u00b1 51.2%;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02). Moreover, hemoglobin levels increased from 9.7 \u00b1 1.9 g\/dL to 11.7 \u00b1 1.2 g\/dL (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) and lost days decreased from 8.2 \u00b1 3.3 days to 1.3 \u00b1 1.5 days (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003) in the LNG\u2010IUS group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the rate of treatment failure was similar in both groups, the LNG\u2010IUS was more effective in reducing MBL than the COC in women with fibroid\u2010related menorrhagia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2010.08.009","type":"journal-article","created":{"date-parts":[[2010,11,20]],"date-time":"2010-11-20T04:24:03Z","timestamp":1290227043000},"page":"126-130","source":"Crossref","is-referenced-by-count":108,"title":["A randomized clinical trial of a levonorgestrel\u2010releasing intrauterine system and a low\u2010dose combined oral contraceptive for fibroid\u2010related menorrhagia"],"prefix":"10.1002","volume":"112","author":[{"given":"Gamal H.","family":"Sayed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud S.","family":"Zakherah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif A.","family":"El\u2010Nashar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh M.","family":"Shaaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","unstructured":"LethabyA.E. 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