{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:17:58Z","timestamp":1790248678429,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl J Gynecology &amp; Obste"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the clinical outcomes of letrozole and laparoscopic ovarian drilling (LOD) in patients with clomiphene\u2010citrate\u2010resistant polycystic ovary syndrome (PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In the present prospective randomized trial, 140 women with clomiphene\u2010citrate\u2010resistant PCOS were randomly allocated to receive 5 mg letrozole from day 3 to day 7 of menses for 6 consecutive cycles, or to undergo LOD. When a leading follicle of at least 18 mm was present, ovulation was triggered with human chorionic gonadotropin (hCG). The 6\u2010month rates of ovulation, pregnancy, abortion, and live births were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The groups were similar with regard to baseline clinical characteristics and hormonal profiles. The ovulation rate was significantly higher in the letrozole group than in the LOD group (59.0% versus 47.5%). On the days of the hCG injection, women in the letrozole group had a significantly thicker endometrium than those in the LOD group (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.0001). Women receiving letrozole had a higher pregnancy rate (35.7% versus 28.6%) and a lower rate of spontaneous abortion (8.0% versus 20.0%, respectively), but these differences were not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Letrozole seems to be a suitable second\u2010line ovulation\u2010inducing alternative to LOD in women with PCOS who do not conceive with clomiphene citrate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijgo.2010.11.026","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T07:45:44Z","timestamp":1302853544000},"page":"218-221","source":"Crossref","is-referenced-by-count":31,"title":["RETRACTED: Reproductive outcome after letrozole versus laparoscopic ovarian drilling for clomiphene\u2010resistant polycystic ovary syndrome"],"prefix":"10.1002","volume":"113","author":[{"given":"Mohamad S.","family":"Abdellah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,1]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063971"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei042"},{"issue":"2","key":"e_1_2_6_4_2","first-page":"93","article-title":"Effect of high dose, short course dexamethasone in clomiphene citrate resistant women with polycystic ovary syndrome","volume":"7","author":"Parsanezhad M.E.","year":"2002","journal-title":"Middle East Fertil Soc J"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)04206-1"},{"issue":"1","key":"e_1_2_6_6_2","first-page":"CD002249","article-title":"Oral anti\u2010oestrogens and medical adjuncts for subfertility associated with anovulation","author":"Beck J.I.","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e328332d188"},{"key":"e_1_2_6_8_2","first-page":"67","volume-title":"Treatment of infertility in PCOS: surgery and laser diathermy","author":"Palomba S.","year":"2006"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg311"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.12.3.353"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.05.002"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh712"},{"key":"e_1_2_6_14_2","volume-title":"WHO Laboratory Manual for the Examination of Human Semen and Sperm\u2010Cervical Mucus Interaction","author":"World Health Organization","year":"1999"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0689"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-008-9284-4"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-008-9209-2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60691-8"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1566-2"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.08.016"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.05.010"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0689"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.08.013"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del020"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03241-7"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.06.014"}],"updated-by":[{"DOI":"10.1002\/ijgo.71388","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000}}],"container-title":["International Journal of Gynecology &amp; 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