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The participants were randomized to receive either double\u2010dose (50 mg\/m<jats:sup>2<\/jats:sup> intramuscularly on days 0 and 4; group 1) or single\u2010dose (50 mg\/m<jats:sup>2<\/jats:sup> intramuscularly on day 0; group 2) methotrexate. Serum human chorionic gonadotropin (\u03b2\u2010hCG) levels were followed until negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall success rate was comparable between groups 1 and 2 (88.6% versus 82.0%, <jats:italic>P<\/jats:italic> = 0.1). The duration of follow up until negative \u03b2\u2010hCG was shorter in group 1 (<jats:italic>P<\/jats:italic> = 0.001). Receiver operative characteristics showed that higher cut\u2010off levels of \u03b2\u2010hCG and gestational mass diameter were associated with successful outcome in group 1. Among participants with initial \u03b2\u2010hCG of 3600\u20135500 mIU\/mL, the success rate was higher in group 1 (<jats:italic>P<\/jats:italic> = 0.03). There was no significant difference between groups in adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For treatment of EP, double\u2010dose methotrexate had efficacy and safety comparable to that of single\u2010dose methotrexate; it had better success among patients with moderately high \u03b2\u2010hCG and led to a shorter follow up.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijgo.2011.08.009","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T22:21:02Z","timestamp":1320099662000},"page":"67-71","source":"Crossref","is-referenced-by-count":46,"title":["Comparison of double\u2010 and single\u2010dose methotrexate protocols for treatment of ectopic pregnancy"],"prefix":"10.1002","volume":"116","author":[{"given":"Hossam O.","family":"Hamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah R.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Alghasham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(99)80046-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199506000-00018"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70343-6"},{"issue":"5","key":"e_1_2_6_5_2","first-page":"749","article-title":"Methotrexate treatment of unruptured ectopic pregnancy: a report of 100 cases","volume":"77","author":"Stovall T.G.","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)49816-X"},{"issue":"5","key":"e_1_2_6_7_2","first-page":"754","article-title":"Single\u2010dose methotrexate for treatment of ectopic pregnancy","volume":"77","author":"Stovall T.G.","year":"1991","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.11.055"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.061"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2005.24.5.591"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200304000-00028"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.06.054"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01547-8"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912233412604"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.12.007"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53779-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90687-E"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(92)90385-V"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.03.066"},{"key":"e_1_2_6_20_2","unstructured":"The Royal College of Obstetricians and Gynecologists.The Management of Tubal Pregnancy.www.gyncph.dk.http:\/\/www.gyncph.dk\/exut\/rcog_management%20of%20tubal.pdf. 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